Simon C, Brandenberger G, Follenius M
Laboratoire de Physiologie et de Psychologie Environnementales, U.M.R. 32 CNRS/INRS, Strasbourg, France.
J Clin Endocrinol Metab. 1988 Jul;67(1):203-5. doi: 10.1210/jcem-67-1-203.
The existence of the dawn phenomenon, defined as an increase in plasma glucose levels and/or insulin requirements in the early morning hours, is well established in diabetic patients but remains controversial in normal subjects. To verify whether this phenomenon occurs in normal subjects, the nocturnal profiles in plasma glucose, insulin, and C-peptide levels; insulin to glucose ratio; and prehepatic insulin production were studied at short intervals (4 and 10 min) in 10 normal men. The first part of the night was characterized by a decrease in all values and the presence of 1 or 2 postprandial fluctuations, followed by a steady state until 0800 h. The individual profiles were frequently superimposable, with rapid 8- to 14-min oscillations. These results do not indicate the existence of a dawn phenomenon in normal subjects.
黎明现象的存在，定义为清晨时段血浆葡萄糖水平和/或胰岛素需求增加，在糖尿病患者中已得到充分证实，但在正常受试者中仍存在争议。为了验证这种现象是否发生在正常受试者中，对10名正常男性进行了短时间间隔（4分钟和10分钟）的血浆葡萄糖、胰岛素和C肽水平的夜间监测；胰岛素与葡萄糖比值；以及肝前胰岛素生成情况。夜间的第一部分表现为所有值均下降，并出现1次或2次餐后波动，随后直至08:00 h处于稳定状态。个体监测结果常常可相互叠加，伴有8至14分钟的快速振荡。这些结果并未表明正常受试者中存在黎明现象。
