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研究正相液相色谱中固定相和流动相极性对大麻素保留的影响。

Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography.

机构信息

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara, Italy.

KNAUER Wissenschaftliche Geräte GmbH, Hegauer Weg 38, 14163, Berlin, Germany.

出版信息

Anal Bioanal Chem. 2022 Jul;414(18):5385-5395. doi: 10.1007/s00216-021-03862-y. Epub 2022 Feb 10.

Abstract

This work reports about a screening of four adsorbents with different polarity employed for the separation of the main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect of polarity and type of interaction mechanisms of the adsorbents (namely Si-, CN-, Diol-, and NH-based SPs) on retention has been investigated under a variety of conditions either by using different combinations of apolar solvents (heptane or hexane) and alcohols (ethanol or isopropanol). The columns have also been employed for the separation of a real cannabis sample. Graphical Abstract Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography.

摘要

本工作报道了四种不同极性的吸附剂在正相液相色谱(NPLC)中用于分离大麻中主要植物大麻素的筛选。考察了吸附剂(即 Si-、CN-、二醇-和 NH 基 SP)的极性和相互作用机制类型对保留的影响,方法是在各种条件下使用不同的非极性溶剂(庚烷或己烷)和醇(乙醇或异丙醇)组合。这些柱子还被用于分离真实的大麻样品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a50b/9242945/9b16d7967e7e/216_2021_3862_Figa_HTML.jpg

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