Shungu D L, Cerami A T, Weinberg E, Capizzi T, Gadebusch H H
J Clin Microbiol. 1986 Mar;23(3):421-4. doi: 10.1128/jcm.23.3.421-424.1986.
Imipenem is a member of a new class of highly potent beta-lactam antibiotics, carbapenems, with a very broad antibacterial spectrum. This study was undertaken to determine tentative interpretive criteria for in vitro susceptibility testing with 10-micrograms imipenem disks. A careful examination of the zone diameters and the corresponding MICs for 489 clinical isolates by regression-line analysis and the error rate-bounded classification scheme suggested the following guidelines: greater than or equal to 16 mm with an MIC correlate of less than or equal to 4 micrograms/ml for susceptible, 14 to 15 mm (8 micrograms/ml) for moderately susceptible, and less than or equal to 13 mm (greater than or equal to 16 micrograms/ml) for resistant. Lack of cross-resistance between imipenem and broad-spectrum cephalosporins such as cefotaxime and ceftazidime argues against their use as class disks to predict in vitro susceptibility of bacterial species to carbapenems.
亚胺培南是一类新型强效β-内酰胺抗生素（碳青霉烯类）的成员，具有非常广泛的抗菌谱。本研究旨在确定用含10微克亚胺培南的纸片进行体外药敏试验的初步解释标准。通过回归线分析和误差率限定分类方案对489株临床分离株的抑菌圈直径和相应的最低抑菌浓度进行仔细检查后，得出以下指导原则：抑菌圈直径大于或等于16毫米且最低抑菌浓度小于或等于4微克/毫升为敏感，14至15毫米（8微克/毫升）为中度敏感，小于或等于13毫米（大于或等于16微克/毫升）为耐药。亚胺培南与广谱头孢菌素（如头孢噻肟和头孢他啶）之间不存在交叉耐药性，这表明它们不能用作类别纸片来预测细菌对碳青霉烯类的体外药敏情况。
