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使用Leu M1和抗上皮膜抗原单克隆抗体诊断霍奇金病。

Use of Leu M1 and antiepithelial membrane antigen monoclonal antibodies for diagnosing Hodgkin's disease.

作者信息

Jack A S, Cunningham D, Soukop M, Liddle C N, Lee F D

出版信息

J Clin Pathol. 1986 Mar;39(3):267-70. doi: 10.1136/jcp.39.3.267.

DOI:10.1136/jcp.39.3.267
PMID:3514684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC499760/
Abstract

Biopsies of 82 patients diagnosed as having Hodgkin's disease were reviewed. Seventeen were reclassified histologically as non-Hodgkin's lymphoma or reactive lymphoid hyperplasia. A substantial number of cases of Hodgkin's disease were negative when stained with Leu M1. Staining for Leu M1 was not found in the cases of non-Hodgkin's lymphoma or reactive lymphoid hyperplasia. With the exception of the lymphocyte predominant nodular subtype of Hodgkin's disease, epithelial membrane antigen staining was seen in a few cases of Hodgkin's disease and non-Hodgkin's lymphomas. This was not a useful discriminating feature.

摘要

对82例被诊断为霍奇金病的患者的活检标本进行了复查。其中17例经组织学重新分类为非霍奇金淋巴瘤或反应性淋巴样增生。相当数量的霍奇金病病例用Leu M1染色时呈阴性。在非霍奇金淋巴瘤或反应性淋巴样增生病例中未发现Leu M1染色。除霍奇金病的淋巴细胞为主型结节亚型外，少数霍奇金病和非霍奇金淋巴瘤病例可见上皮膜抗原染色。这不是一个有用的鉴别特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c93/499760/1c0a4ad6606b/jclinpath00198-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c93/499760/6d5cb5045f8c/jclinpath00198-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c93/499760/d1d7ca317cbf/jclinpath00198-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c93/499760/1c0a4ad6606b/jclinpath00198-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c93/499760/6d5cb5045f8c/jclinpath00198-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c93/499760/d1d7ca317cbf/jclinpath00198-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c93/499760/1c0a4ad6606b/jclinpath00198-0033-b.jpg

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引用本文的文献

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本文引用的文献

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Am J Clin Pathol. 1984 Jul;82(1):29-32. doi: 10.1093/ajcp/82.1.29.
2
The prognostic significance of cellular subtypes in nodular sclerosing Hodgkin's disease: an analysis of 271 non-laparotomised cases (BNLI report no. 22).结节硬化型霍奇金淋巴瘤细胞亚型的预后意义：271例非剖腹手术病例分析（英国国家淋巴瘤调查组报告第22号）
Clin Radiol. 1983 Sep;34(5):497-501. doi: 10.1016/s0009-9260(83)80148-2.
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Immunohistological analysis of human lymphoma: correlation of histological and immunological categories.
免疫组织化学在淋巴瘤诊断中的应用
Br Med J (Clin Res Ed). 1986 Dec 13;293(6561):1520-1. doi: 10.1136/bmj.293.6561.1520.
4
Comparative quality assessment in immunocytochemistry: pilot study of CD15 staining in paraffin wax embedded tissue in Hodgkin's disease.免疫细胞化学中的比较质量评估：霍奇金病石蜡包埋组织中CD15染色的初步研究。
J Clin Pathol. 1989 Oct;42(10):1096-100. doi: 10.1136/jcp.42.10.1096.
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Distinction between cells in serous effusions using a panel of antibodies.使用一组抗体区分浆液性积液中的细胞。
Virchows Arch A Pathol Anat Histopathol. 1987;411(3):299-304. doi: 10.1007/BF00735037.
人类淋巴瘤的免疫组织学分析：组织学与免疫学分类的相关性
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