CD15免疫染色在霍奇金淋巴瘤诊断中的价值：已发表文献综述
Value of CD15 immunostaining in diagnosing Hodgkin's disease: a review of published literature.
作者信息
Hall P A, D'Ardenne A J
机构信息
Department of Histopathology, St Bartholomew's Hospital, London.
出版信息
J Clin Pathol. 1987 Nov;40(11):1298-304. doi: 10.1136/jcp.40.11.1298.
Abstract
The role of antibodies of CD15 as diagnostic markers of Hodgkin's disease was assessed from a review of the literature. A total of 571 cases of Hodgkin's disease and 386 cases of non-Hodgkin's lymphoma were included. The sensitivity of CD15 in detecting cases of Hodgkin's disease was 80% or 91% if cases of lymphocyte predominant Hodgkin's disease were excluded. The specificity of CD15 was only 80.6%, or in other words, 19.4% of cases of non-Hodgkin's lymphoma were CD15 positive. In an ideal test both the sensitivity and specificity would be 100% and if the test performance were no better than chance then they would both be 50%. It is concluded that CD15 immunostaining cannot be regarded as a sensitive or specific marker of Hodgkin's disease. Application of this formal method of analysis to other immunohistological reagents and panels of antibodies is discussed.
摘要
通过文献综述评估了CD15抗体作为霍奇金病诊断标志物的作用。共纳入571例霍奇金病病例和386例非霍奇金淋巴瘤病例。如果排除淋巴细胞为主型霍奇金病病例，CD15检测霍奇金病病例的敏感性为80%或91%。CD15的特异性仅为80.6%，换言之，19.4%的非霍奇金淋巴瘤病例CD15呈阳性。在理想的检测中，敏感性和特异性均应为100%，如果检测性能不比随机情况更好，那么两者均应为50%。结论是，CD15免疫染色不能被视为霍奇金病的敏感或特异性标志物。讨论了将这种正式分析方法应用于其他免疫组织化学试剂和抗体组合的情况。
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本文引用的文献
1
Application of the predictive value model in the analysis of test effectiveness.预测值模型在检验效能分析中的应用。
Clin Lab Med. 1982 Dec;2(4):685-99.
2
Mistaken clinical and pathologic diagnoses of Hodgkin's disease: a Southwest oncology group study.霍奇金病的临床与病理误诊：西南肿瘤协作组研究
Cancer Treat Rep. 1982 Apr;66(4):645-51.
3
The declining specificity of exercise radionuclide ventriculography.运动放射性核素心室造影术特异性的下降。
N Engl J Med. 1983 Sep 1;309(9):518-22. doi: 10.1056/NEJM198309013090902.
4
Immunoglobulin light chain staining of lymph node biopsies: an interlaboratory comparison.
Ann Clin Lab Sci. 1981 Nov-Dec;11(6):525-9.
5
Leu M1 and peanut agglutinin stain the neoplastic cells of Hodgkin's disease.白细胞共同抗原M1和花生凝集素可使霍奇金病的肿瘤细胞着色。
Am J Clin Pathol. 1984 Jul;82(1):29-32. doi: 10.1093/ajcp/82.1.29.
6
Evidence for the detection of the normal counterpart of Hodgkin and Sternberg-Reed cells.检测霍奇金细胞和施特恩伯格-里德细胞正常对应物的证据。
Hematol Oncol. 1983 Jan-Mar;1(1):21-9. doi: 10.1002/hon.2900010105.
7
Selection and interpretation of diagnostic tests and procedures. Principles and applications.诊断检查和程序的选择与解读。原理及应用。
Ann Intern Med. 1981 Apr;94(4 Pt 2):557-92.
8
Immunohistological analysis of human lymphoma: correlation of histological and immunological categories.人类淋巴瘤的免疫组织学分析：组织学与免疫学分类的相关性
Adv Cancer Res. 1984;42:67-147. doi: 10.1016/s0065-230x(08)60456-x.
9
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