基于羧酸柱[5]芳烃的 pH 触发型超分子光动力抗菌增效剂。
A carboxylatopillar[5]arene-based pH-triggering supramolecular photosensitizer for enhanced photodynamic antibacterial efficacy.
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Chem Commun (Camb). 2022 Mar 1;58(18):2991-2994. doi: 10.1039/d1cc06116j.
PMID:35147152
Abstract
A pH-triggering supramolecular antibacterial photosensitizer was constructed by host-guest interaction between a water-soluble porphyrin photosensitizer and carboxylatopillar[5]arene (P[5]). The formation of the supramolecular complex not only improves the biocompatibility of the photosensitizer, but also enhances antibacterial efficacy by pH-triggering dissociation under the low pH bacterial microenvironment.
摘要
通过水溶性卟啉光敏剂与羧酸柱[5]芳烃（P[5]）之间的主客体相互作用，构建了一种 pH 触发的超分子抗菌光敏剂。超分子复合物的形成不仅提高了光敏剂的生物相容性，而且还通过在低 pH 细菌微环境下 pH 触发解离增强了抗菌功效。
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