Hesse B, Rasmussen S, Giese J, Damkjaer Nielsen M, Høilund-Carlsen P F
J Hypertens. 1986 Feb;4(1):113-9. doi: 10.1097/00004872-198602000-00018.
Plasma renin (PRC) and angiotensin I (pANG I) and II (pANG II) concentrations were determined at renal vein catheterization in 38 hypertensive patients suspected of renal or renovascular aetiology. Veno-arterial differences in pANG I across the affected kidney in patients with lateralization of the renin secretion indicated release of angiotensin I (ANG I) in considerable amounts. Veno-arterial differences in pANG II of around zero indicated that generation and elimination of angiotensin II (ANG II) were equal in that kidney. Across the contralateral kidney the veno-arterial differences in PRC and pANG II were both close to zero, while negative differences in pANG II indicated the removal of ANG II. In patients without lateralization of the renin secretion the veno-arterial differences in pANG I were close to zero or positive, those of pANG II being close to zero or negative. In 14 of the 38 patients, data were obtained either during maintenance treatment with captopril or after a single dose of this converting enzyme inhibitor. Systemic PRC and pANG I values were extremely high and pANG II values low. The pANG I gradient across the affected kidney was further increased compared with pre-captopril levels, whereas the contralateral kidney still eliminated ANG I.
在38例怀疑患有肾性或肾血管性病因的高血压患者进行肾静脉插管时，测定了血浆肾素（PRC）、血管紧张素I（pANG I）和血管紧张素II（pANG II）的浓度。肾素分泌有侧别差异的患者，患侧肾脏的pANG I动静脉差值表明有大量血管紧张素I（ANG I）释放。pANG II的动静脉差值约为零，表明该肾脏中血管紧张素II（ANG II）的生成和消除相等。对侧肾脏的PRC和pANG II动静脉差值均接近零，而pANG II的负差值表明有ANG II的清除。在肾素分泌无侧别差异的患者中，pANG I的动静脉差值接近零或为正值，pANG II的差值接近零或为负值。在38例患者中的14例，数据是在使用卡托普利维持治疗期间或单次服用这种转换酶抑制剂后获得的。全身PRC和pANG I值极高，而pANG II值很低。与服用卡托普利前相比，患侧肾脏的pANG I梯度进一步增加，而对侧肾脏仍能清除ANG I。
