Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
Department of Radiology, Iran University of Medical Sciences, Tehran, Iran.
BMC Womens Health. 2022 Feb 11;22(1):33. doi: 10.1186/s12905-022-01607-2.
This study aimed to compare the effect of ovarian suspension and hyaluronic acid gel to prevent re-adhesions after laparoscopic endometrioma surgery.
This randomized clinical trial was conducted at Rasoul-e-Akram and Pars Hospitals, Tehran, Iran, 2016-18. Fifty patients with bilateral endometrioma and pelvic adhesions, the candidates of laparoscopic surgery, were included. In each patient, at the end of ovarian cystectomy and adhesiolysis, one of the ovaries was randomly sutured to the abdominal wall, and the HYAcorp Endogel covered the other; the adhesion rate was compared between the groups by ultrasonography, three-month after surgery.
Mean age of patients was 32.6 years. Presurgical variables were similar between right and left ovaries and the study groups (P > 0.05). Postsurgical ultrasonography showed that ovarian soft markers, including < 1/3 ovarian adhesions (minimal adhesions) in 80.5% of ovaries of the Endogel group and 35.5% of the ovarian suspension group (P < 0.001) with higher ovarian mobility in the Endogel group (65% vs. 22%) (P = 0.001). In addition, site-specific tenderness and ovarian fading margin were lower in the Endogel group (P < 0.001). Trial registration Clinical trial registry number: IRCT2015081723666N1, 12.19.2015, Date of registration: 01/02/2016; https://en.irct.ir/trial/20174?revision=20174 . Date and number of IRB: 2015, I.R.IUMS.REC.1394.24703.
Hyaluronic acid gel can be more effective than ovarian suspension in preventing ovarian adhesions after laparoscopic treatment of endometriosis.
本研究旨在比较卵巢悬吊带和透明质酸凝胶预防腹腔镜子宫内膜异位症手术后粘连的效果。
这是一项在伊朗德黑兰 Rasoul-e-Akram 和 Pars 医院进行的随机临床试验，于 2016 年至 2018 年进行。共纳入 50 例双侧子宫内膜异位症合并盆腔粘连的患者，这些患者均适合接受腹腔镜手术。在每例患者中，在卵巢囊肿切除术和粘连松解术结束时，一侧卵巢随机缝合至腹壁，另一侧卵巢用 HYAcorp Endogel 覆盖；术后 3 个月通过超声检查比较两组的粘连发生率。
患者的平均年龄为 32.6 岁。右侧和左侧卵巢以及研究组之间的术前变量相似（P＞0.05）。术后超声检查显示，透明质酸凝胶组卵巢软指标的卵巢粘连程度较轻（＜1/3 的卵巢粘连[轻度粘连]，发生率为 80.5%），而卵巢悬吊带组的发生率为 35.5%（P＜0.001）；透明质酸凝胶组的卵巢活动度更高（65% vs. 22%）（P=0.001）。此外，透明质酸凝胶组的卵巢触痛和卵巢边界模糊程度更低（P＜0.001）。
临床试验注册号：IRCT2015081723666N1，2015 年 12 月 19 日；注册日期：2016 年 2 月 1 日；https://en.irct.ir/trial/20174 ？revision=20174 。IRB 的日期和编号：2015 年，IR.IUMS.REC.1394.24703。
与卵巢悬吊带相比，透明质酸凝胶在预防腹腔镜治疗子宫内膜异位症后卵巢粘连方面更有效。
