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Calpain-1 inhibition attenuates in vivo thrombosis in a humanized model of sickle cell disease.

作者信息

Mithila Farha, Schwake Christopher, Fang Chao, Merrill-Skoloff Glenn, Covic Lidija, Fritz Daniel I, Hanada Toshihiko, Flaumenhaft Robert, Chishti Athar H

机构信息

Department of Developmental, Molecular, and Chemical Biology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

出版信息

Thromb Res. 2022 Mar;211:123-126. doi: 10.1016/j.thromres.2022.01.029. Epub 2022 Feb 4.

DOI:10.1016/j.thromres.2022.01.029
PMID:35149397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9207783/
Abstract
摘要

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本文引用的文献

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COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals.COVID-19 与镰状细胞病/镰状细胞特征个体和其他黑人个体相比。
Blood Adv. 2021 Apr 13;5(7):1915-1921. doi: 10.1182/bloodadvances.2020003741.
2
COVID-19 patient with coronary thrombosis supported with ECMO and Impella 5.0 ventricular assist device: a case report.一名患有冠状动脉血栓形成的COVID-19患者接受体外膜肺氧合（ECMO）和Impella 5.0心室辅助装置支持：病例报告
Eur Heart J Case Rep. 2020 Nov 20;4(6):1-6. doi: 10.1093/ehjcr/ytaa342. eCollection 2020 Dec.
3
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.钙蛋白酶-1在镰状细胞病的人源化小鼠模型中调节血小板功能。
Thromb Res. 2017 Dec;160:58-65. doi: 10.1016/j.thromres.2017.10.018. Epub 2017 Oct 26.
4
Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease.钙蛋白酶-1的基因失活可减轻镰状细胞病人类化小鼠模型的疼痛敏感性。
Haematologica. 2016 Oct;101(10):e397-e400. doi: 10.3324/haematol.2016.148106. Epub 2016 Jul 14.
5
Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.钙蛋白酶-1 敲除揭示了其对红细胞变形性和生理学的广泛影响。
Biochem J. 2012 Nov 15;448(1):141-52. doi: 10.1042/BJ20121008.
6
Calcium signaling in platelets.血小板中的钙信号传导。
J Thromb Haemost. 2009 Jul;7(7):1057-66. doi: 10.1111/j.1538-7836.2009.03455.x. Epub 2009 Apr 24.
7
Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets.双敲除实验表明，蛋白酪氨酸磷酸酶1B是血小板中钙蛋白酶-1的生理靶点。
Mol Cell Biol. 2007 Sep;27(17):6038-52. doi: 10.1128/MCB.00522-07. Epub 2007 Jun 18.
8
Disruption of the mouse mu-calpain gene reveals an essential role in platelet function.小鼠μ-钙蛋白酶基因的破坏揭示了其在血小板功能中的重要作用。
Mol Cell Biol. 2001 Mar;21(6):2213-20. doi: 10.1128/MCB.21.6.2213-2220.2001.
9
Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIbbeta3) in von Willebrand factor-induced signal transduction.钙蛋白酶对血管性血友病因子刺激的血小板中细胞骨架信号复合物的调节。糖蛋白Ib-V-IX和糖蛋白IIb-IIIa（整合素αIIbβ3）在血管性血友病因子诱导的信号转导中的不同作用。
J Biol Chem. 1997 Aug 29;272(35):21847-54. doi: 10.1074/jbc.272.35.21847.
10
Elevated erythrocyte calcium in sickle cell disease.镰状细胞病中红细胞钙升高。
Nature. 1973 Nov 9;246(5428):105-6. doi: 10.1038/246105a0.