Department of Strategic Surveillance for Functional Food and Comprehensive Traditional Medicine, Wakayama Medical University, Wakayama, Japan.
Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
Biosci Biotechnol Biochem. 2022 Mar 21;86(4):528-534. doi: 10.1093/bbb/zbac013.
The fruit of Prunus mume (ume, also known as Japanese apricot) has been used as a functional food in Japan since ancient times. We previously reported that ume stimulates the differentiation of preosteoblastic cells. Osteocalcin (OCN) is secreted by osteoblasts, and there is known association with glucolipid metabolism and cognitive function. This study sought to clarify the relationship between ume extracts and OCN production both in vitro and in vivo. Alkaline phosphatase activity and OCN level in the ethyl acetate extracts of ume-treated extracts were significantly increased in preosteoblast MC3T3-E1 cells compared with the control group. In human study, serum OCN level was significantly higher in the high ume intake group than in the low intake group in community-dwelling participants over 60 years old. These results suggest that ume has the potential to upregulated OCN production both in vitro and in vivo.
青梅（也称为日本杏）的果实自古以来就在日本被用作功能性食品。我们之前报道过，青梅可刺激前成骨细胞的分化。骨钙素（OCN）是由成骨细胞分泌的，与糖脂代谢和认知功能有关。本研究旨在阐明青梅提取物在体外和体内与 OCN 产生的关系。与对照组相比，用青梅处理的提取物的乙酸乙酯提取物可显著增加成骨细胞 MC3T3-E1 细胞中的碱性磷酸酶活性和 OCN 水平。在人类研究中，与低青梅摄入量组相比，社区居住的 60 岁以上参与者中，高青梅摄入量组的血清 OCN 水平显著更高。这些结果表明，青梅具有在体外和体内均能上调 OCN 产生的潜力。
