Kim Jeong-Ki, Park Yong-Gum, Kim Beom Gyu
Department of Surgery (Colorerctal Division), Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-Ro, Dongjak-gu, 06973, Seoul, Republic of Korea.
Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Genes Genomics. 2022 Mar;44(3):389-394. doi: 10.1007/s13258-022-01221-4. Epub 2022 Feb 12.
Anorectal condyloma is the representative venereal disease caused by human papilloma virus (HPV), which has more 180 subtypes. Although there are various known risk factors for recurrence, few studies have investigated the influence of HPV subtypes.
We aimed to investigate the correlation between the recurrence of anorectal condyloma and HPV subtypes.
We analyzed the clinical and histopathological information of 143 patients who underwent surgery for anorectal condyloma at the National Medical Center between March 2016 and September 2020. PCR analyses were performed to confirm the HPV subtype in 24 patients.
Recurrence was confirmed in 63 patients through outpatient follow-up over a median of 31.7 months (range: 0-56.2) after surgery. Recurrence was significantly associated with anorectal condyloma severity (p < 0.001), but there were no differences between the primary and recurrent groups, CD4-positive cell counts, or human immunodeficiency virus loads. The high-risk HPV subtype was associated with a high recurrence rate. Furthermore, the overall recurrence rate in anorectal condyloma patients was 44.1%.
These results suggest that recurrence of anorectal condyloma has a significant association with high-risk HPV subtypes. Therefore, it is necessary to check for recurrences during follow-up after surgery.
肛门直肠尖锐湿疣是由人乳头瘤病毒（HPV）引起的典型性传播疾病，HPV有180多种亚型。尽管已知有多种复发风险因素，但很少有研究调查HPV亚型的影响。
我们旨在研究肛门直肠尖锐湿疣复发与HPV亚型之间的相关性。
我们分析了2016年3月至2020年9月期间在国家医疗中心接受肛门直肠尖锐湿疣手术的143例患者的临床和组织病理学信息。对24例患者进行了PCR分析以确认HPV亚型。
通过门诊随访，在术后中位时间31.7个月（范围：0 - 56.2个月）确认63例患者复发。复发与肛门直肠尖锐湿疣严重程度显著相关（p < 0.001），但原发组与复发组之间、CD4阳性细胞计数或人类免疫缺陷病毒载量无差异。高危HPV亚型与高复发率相关。此外，肛门直肠尖锐湿疣患者的总体复发率为44.1%。
这些结果表明，肛门直肠尖锐湿疣的复发与高危HPV亚型显著相关。因此，术后随访期间有必要检查是否复发。
