Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Cultivation Base of MOST, Laboratory of Quality and Safety Risk Assessment for Agro-products of Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Cultivation Base of MOST, Laboratory of Quality and Safety Risk Assessment for Agro-products of Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China; College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture and Rural Affairs, Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control, Zhejiang University, Hangzhou, 310058, China.
Environ Pollut. 2022 May 15;301:118980. doi: 10.1016/j.envpol.2022.118980. Epub 2022 Feb 9.
Selenium is an essential trace element for humans and obtained from diary diets. The consumption of selenium-rich agricultural food is an efficient way to obtain selenium, but the quality and safety of selenium-rich agro-food are always affected by their associated heavy metals, even poses a potential threaten to human health. In this research, a sampling survey of heavy metals contents in selenium-rich rice was conducted, 182 sets of selenium-rich rice samples were collected from five selenium-rich rice-producing areas of China, and the accumulation of selenium and cadmium were found to be associated in rice and soil. Subsequently, a pot experiment was performed in the greenhouse via treating the soil samples with 12 different concentrations of selenium and heavy metals, and the contents of selenium and cadmium in rice grain were confirmed to be significantly associated. Moreover, transcriptome analysis revealed that the up-regulation of transporter-coding may promote the absorption of selenium and cadmium. The expression of antioxidant-coding genes and cadmium chelator transporter coding-genes was up-regulated to reduce the toxicity of cadmium. Meanwhile, the up-regulation of key genes of the ascorbic acid-glutathione metabolic pathway were responsible for the association between selenium and cadmium in Se-rich rice. Our work suggested the correlation between selenium and cadmium accumulation in selenium-rich rice, clarified their accumulation mechanism, provides a direction for the scientific production of selenium-rich agro-foods.
硒是人体必需的微量元素，主要从膳食中获得。富硒农业食品的消费是获取硒的有效途径，但富硒农产品的质量和安全总是受到其相关重金属的影响，甚至对人类健康构成潜在威胁。本研究对富硒大米中的重金属含量进行了抽样调查，从中国五个富硒大米产区采集了 182 组富硒大米样品，发现大米和土壤中的硒和镉存在相关性。随后，在温室中通过用 12 种不同浓度的硒和重金属处理土壤样品进行了盆栽实验，证实了大米中硒和镉的含量显著相关。此外，转录组分析表明，转运蛋白编码基因的上调可能促进了硒和镉的吸收。抗氧化剂编码基因和镉螯合转运蛋白编码基因的表达上调，降低了镉的毒性。同时，富硒大米中抗坏血酸-谷胱甘肽代谢途径关键基因的上调也解释了硒和镉之间的相关性。本研究阐明了富硒大米中硒和镉的积累机制，为富硒农产品的科学生产提供了方向。
