Department of Oral and Maxillofacial Surgery, Rouen University Hospital, Rouen Normandy University, 1 rue de Germont, Rouen F-76000, France.
Haemophilia Treatment Centre, Laboratory of Hematology, Rouen University Hospital, Rouen Normandy University, 1 rue de Germont, Rouen F-76000, France.
J Stomatol Oral Maxillofac Surg. 2022 Oct;123(5):e405-e410. doi: 10.1016/j.jormas.2022.02.003. Epub 2022 Feb 9.
The management of patients with inherited bleeding disorders in oral surgery requires the systematic evaluation of bleeding risk and the setting up of an adequate treatment protocol by the referring haematologist, defining a replacement therapy and a recommended length of hospital stay. The purpose of this study was to determine the bleeding risk associated with oral surgery for each type of inherited bleeding disorder and to evaluate the efficacy of the treatment protocols set up in our tertiary care center.
We included all patients with an inherited bleeding disorder, managed in our oral and maxillofacial surgery department with a treatment protocol set up by our local Haemophilia Treatment Centre for an oral surgical procedure.
Between January 2006 and December 2018, 295 treatment protocols were set up for the management of patients with haemorrhagic risk in oral surgical procedures. Of these, 203 were scheduled to take place in our department. A total of 180 oral surgical procedures for 147 patients were included. The incidence of bleeding complications in our study was 4.44% (8 out of 180) with a significantly higher risk in patients with haemophilia, the mean time to onset of bleeding was 11 days.
The use of a treatment protocol for the management of patients with inherited bleeding disorders in oral surgery seems effective. Our rate of bleeding complications was comparable to data in the literature, and often lower.
口腔外科中遗传性出血性疾病患者的管理需要由转诊血液科医生系统评估出血风险，并制定适当的治疗方案，确定替代治疗方法和推荐的住院时间。本研究的目的是确定每种遗传性出血性疾病与口腔手术相关的出血风险，并评估我们的三级护理中心制定的治疗方案的疗效。
我们纳入了所有在口腔颌面外科部门接受治疗方案管理的遗传性出血性疾病患者，这些方案由我们当地的血友病治疗中心为口腔手术制定。
2006 年 1 月至 2018 年 12 月，共为 295 名存在出血风险的患者制定了 203 项口腔手术治疗方案。其中 180 项口腔手术在我们科室进行。共纳入 147 名患者的 180 项口腔手术。研究中出血并发症的发生率为 4.44%（8/180），其中血友病患者的风险显著更高，出血的平均发病时间为 11 天。
在口腔外科中使用治疗方案管理遗传性出血性疾病患者似乎是有效的。我们的出血并发症发生率与文献中的数据相当，且通常更低。
