School of Science and Technology, Nottingham Trent University, United Kingdom.
National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, United Kingdom.
Nutrition. 2022 Apr;96:111589. doi: 10.1016/j.nut.2022.111589. Epub 2022 Jan 7.
Short periods of excessive consumption of indulgent high-fat foods are common in Western society, but the effect this has on bone is unknown. The aim of this pilot study was to explore how a 7-d hyperenergetic, high-fat diet affects candidate biomarkers of bone metabolism.
The study included 12 healthy men with a mean age of 24 y (SD = 4 y) and body mass index (BMI) of 24.1 kg/m (SD = 1.5). The men consumed a 7-d hyperenergetic, high-fat diet (HE-HFD; 20.9 [SD = 0.8] MJ; 65% total energy as fat) and a control (CON) diet (10.9 [SD = 2] MJ; 36% total energy as fat), in randomized, crossover order, with each trial separated by 3 wk. Markers of bone formation (P1NP) and bone resorption (CTx) were measured at baseline and after 1, 3, and 7 d of each diet. Bone metabolic responses were analyzed using two-factor repeated-measures analysis of variance and subsequent pairwise comparisons.
There was a main effect of time (P < 0.05), but no trial (P = 0.270) or time- × -trial interaction (P = 0.693) effects for plasma concentrations of CTx. Mean CTx concentrations did not differ between trials (CON: 0.97 ng/mL [SD = 0.39]; HE-HFD: 1.03 ng/mL [SD = 0.22]; P = 0.225). There was a main effect of trial (P < 0.01), but no time (P = 0.138) or trial- × -interaction (P = 0.179) effects for plasma concentrations of P1NP. Mean P1NP concentrations were lower during the HE-HFD (61.79 ng/mL [SD = 26.54]) than during the CON diet (77.89 ng/mL [SD = 28.71]; P < 0.01).
A 7-d hyperenergetic, high-fat diet reduces a marker of bone formation but does not affect a marker of bone resorption. This pilot study suggested that short periods of excessive energy and fat consumption may detrimentally affect bone health.
在西方社会，人们经常会在短时间内摄入过量放纵的高脂肪食物，但目前尚不清楚这对骨骼有何影响。本初步研究旨在探讨为期 7 天的高能量高脂肪饮食如何影响骨代谢的候选生物标志物。
该研究纳入了 12 名平均年龄 24 岁（标准差 4 岁）、体重指数（BMI）为 24.1kg/m（标准差 1.5）的健康男性。这些男性随机交叉摄入为期 7 天的高能量高脂肪饮食（HE-HFD；20.9[标准差 0.8]MJ；总能量的 65%来自脂肪）和对照饮食（CON；10.9[标准差 2]MJ；总能量的 36%来自脂肪），两次试验之间间隔 3 周。在基线和每种饮食的第 1、3 和 7 天时，分别检测骨形成标志物（P1NP）和骨吸收标志物（CTX）。采用双因素重复测量方差分析和后续两两比较分析骨代谢反应。
CTX 血浆浓度存在时间主效应（P<0.05），但无试验（P=0.270）或时间-试验交互作用（P=0.693）效应。两种试验中 CTx 浓度无差异（CON：0.97ng/mL[标准差 0.39]；HE-HFD：1.03ng/mL[标准差 0.22]；P=0.225）。P1NP 血浆浓度存在试验主效应（P<0.01），但无时间（P=0.138）或试验-交互作用（P=0.179）效应。HE-HFD 时 P1NP 浓度（61.79ng/mL[标准差 26.54]）低于 CON 饮食时（77.89ng/mL[标准差 28.71]；P<0.01）。
为期 7 天的高能量高脂肪饮食可降低骨形成标志物，但不影响骨吸收标志物。本初步研究提示，短期过度摄入能量和脂肪可能会对骨骼健康产生不利影响。
