Department of Ophthalmology, Kim's Eye Hospital, Seoul, South Korea.
Retina. 2022 Jun 1;42(6):1028-1037. doi: 10.1097/IAE.0000000000003437.
To evaluate the incidence and characteristics of bacillary layer detachment (BALAD) in neovascular age-related macular degeneration.
This retrospective study was performed at Kim's Eye Hospital in South Korea. Patients who were diagnosed with neovascular age-related macular degeneration between January 2017 and December 2017 were included. The incidence of BALAD was compared among different types of macular neovascularization (MNV). The best-corrected visual acuity and central retinal thickness at diagnosis were compared between patients showing BALAD at diagnosis and those who did not.
Among the 442 patients included, BALAD was observed in 20 patients (4.5%). There was a significant difference in the incidence of BALAD between Type 1 MNV (2.7%), Type 2 MNV (12.5%), and Type 3 MNV (0%) (P < 0.001). The best-corrected visual acuity was significantly worse (mean 1.26 ± 0.79 vs. 0.62 ± 0.50, P = 0.001), and the central retinal thickness was significantly greater (mean 648.2 ± 211.1 µm vs. 464.0 ± 175.5 µm, P < 0.001) in patients with BALAD than in those without it. After antivascular endothelial growth factor therapy, all BALADs resolved.
This study first reported the incidence of the BALAD in neovascular age-related macular degeneration in a Korean population. The incidence of BALAD was the highest in Type 2 MNVs. Bacillary layer detachment generally develops in eyes with great macular thickness and poor visual acuity.
评估新生血管性年龄相关性黄斑变性中细菌层脱离（BALAD）的发生率和特征。
本回顾性研究在韩国 Kim's Eye Hospital 进行。纳入 2017 年 1 月至 2017 年 12 月期间被诊断为新生血管性年龄相关性黄斑变性的患者。比较不同类型的黄斑新生血管（MNV）之间 BALAD 的发生率。比较诊断时出现 BALAD 的患者和未出现 BALAD 的患者的最佳矫正视力和中心视网膜厚度。
在纳入的 442 例患者中，有 20 例（4.5%）观察到 BALAD。1 型 MNV（2.7%）、2 型 MNV（12.5%）和 3 型 MNV（0%）之间 BALAD 的发生率存在显著差异（P<0.001）。出现 BALAD 的患者最佳矫正视力明显较差（平均 1.26±0.79 与 0.62±0.50，P=0.001），中心视网膜厚度明显更大（平均 648.2±211.1μm 与 464.0±175.5μm，P<0.001）。经抗血管内皮生长因子治疗后，所有 BALAD 均消失。
本研究首次在韩国人群中报告了新生血管性年龄相关性黄斑变性中 BALAD 的发生率。BALAD 的发生率在 2 型 MNV 中最高。细菌层脱离通常发生在黄斑厚度大、视力差的眼睛中。
