Vali Sara, Khosravani Sarvin, Nobar Behrad Rahbani, Motamedian Saeed Reza
School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dentofacial Deformities Research Center, Research Institute of Dental Sciences, and Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int Orthod. 2022 Mar;20(1):100614. doi: 10.1016/j.ortho.2022.100614. Epub 2022 Feb 10.
Maxillary constriction is a relatively common condition. Various treatment modalities have been proposed for this condition such as rapid maxillary expansion (RME). Although RME can significantly expand the suture in a relatively short period of time, it has a number of drawbacks, mainly a lengthy retention period. The primary objective of this study was to assess the efficacy of the supplementary methods used in conjunction with RME for new bone formation (NBF) at the midpalatal suture (MPS). Relapse, bone healing, and root resorption were also studied as the secondary outcomes.
The PubMed, Embase, and Cochrane library online databases were searched according to the PRISMA-ScR guideline. Animal studies on the effects of non-surgical supplementary methods other than laser therapy on NBF in RME were included and reviewed.
Thirty-eight articles met the inclusion criteria. The supplementary methods were categorized into 6 groups: hormones, chemical agents, drugs, vitamins, proteins, and some other substances, which could not be assigned to any group. All the aforementioned substances enhanced NBF. Drugs such as bisphosphonates also increased bone resorption. The oestrogen hormone was shown to reduce treatment relapse. Lastly, stem cell application accelerated bone healing at the expanded MPS.
Administration of hormones, chemical agents, drugs, vitamins, herbs, and proteins may improve the outcomes of RME, shorten the retention period and consequently, reduce relapse in animals. However, the generalizability of these findings is limited due to the insubstantial number of studies published on each substance.
上颌骨狭窄是一种相对常见的病症。针对这种病症已经提出了各种治疗方式，例如快速上颌扩弓（RME）。尽管RME能够在相对较短的时间内显著扩开骨缝，但它存在一些缺点，主要是保持期较长。本研究的主要目的是评估与RME联合使用的辅助方法对腭中缝（MPS）处新骨形成（NBF）的疗效。复发、骨愈合和牙根吸收也作为次要结果进行了研究。
根据PRISMA-ScR指南检索了PubMed、Embase和Cochrane图书馆在线数据库。纳入并综述了关于除激光治疗外的非手术辅助方法对RME中NBF影响的动物研究。
38篇文章符合纳入标准。辅助方法分为6组：激素、化学试剂、药物、维生素、蛋白质以及一些无法归入任何一组的其他物质。所有上述物质均促进了NBF。双膦酸盐等药物也增加了骨吸收。雌激素被证明可减少治疗后的复发。最后，干细胞应用加速了扩开的MPS处的骨愈合。
给予激素、化学试剂、药物、维生素、草药和蛋白质可能会改善RME的治疗效果，缩短保持期，从而减少动物的复发。然而，由于针对每种物质发表的研究数量不足，这些发现的可推广性有限。
