来自酒糟的膳食碱稳定中性脂质可抑制小鼠结肠异常隐窝病灶的形成。

Dietary Alkali-stable Neutral Lipids from Sake Lees Suppress the Formation of Colon Aberrant Crypt Foci in Mice.

作者信息

Yamashita Shinji, Tsuruma Tomoya, Kinoshita Mikio, Miyazawa Teruo

机构信息

Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine.

Food Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University.

出版信息

J Oleo Sci. 2022 Mar 2;71(3):419-423. doi: 10.5650/jos.ess21378. Epub 2022 Feb 11.

DOI:10.5650/jos.ess21378

PMID:35153248

Abstract

We have previously reported that dietary glucosylceramide (GlcCer) and rice extracts containing GlcCer reduce the formation of aberrant crypt foci (ACF) in the colons of 1,2-dimethylhydrazine (DMH)-treated mice, as a precursor model of colon cancer. This study investigated the impact of alkali-stable neutral lipids (NLs) containing free ceramides (Cer) and sterols on the formation of ACF in mice for the purpose of searching for functional components, irrespective of GlcCer, in rice extracts. The fraction was prepared from sake lees as a rice fermentation byproduct. Dietary NLs suppressed the marked increase in colon ACF treated with DMH.

摘要

我们之前曾报道，膳食中的葡萄糖神经酰胺（GlcCer）以及含有GlcCer的米提取物可减少1,2 - 二甲基肼（DMH）处理小鼠结肠中异常隐窝灶（ACF）的形成，ACF是结肠癌的一种前体模型。本研究调查了含有游离神经酰胺（Cer）和甾醇的碱稳定中性脂质（NLs）对小鼠ACF形成的影响，目的是在米提取物中寻找不依赖于GlcCer的功能成分。该组分是从作为大米发酵副产物的酒糟中制备的。膳食NLs抑制了用DMH处理的结肠ACF的显著增加。