膳食植物源葡萄糖神经酰胺对经二甲基肼处理小鼠结肠细胞因子含量的影响。
Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice.
作者信息
Yamashita Shinji, Sakurai Riho, Hishiki Kenshiro, Aida Kazuhiko, Kinoshita Mikio
机构信息
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine.
出版信息
J Oleo Sci. 2017;66(2):157-160. doi: 10.5650/jos.ess16169.
In this study, the effects of dietary plant-origin glucosylceramide (GlcCer) on colon cytokine contents were investigated in 1,2-dimethylhydrazine (DMH)-treated mice, a model of colon cancer. DMH treatment induced the formation of aberrant crypt foci (ACF) and the production of inflammatory cytokines and chemokaines. Dietary GlcCer suppressed ACF formation and cytokine production in these mice. In particular, chemokine production was suppressed by dietary GlcCer. These GlcCer-related trends of suppression were similar to those observed in our previous study on dextran sulfate sodium salt (DSS)-treated mice. These results provide further evidence for the suppression of DMH-induced inflammation by dietary GlcCer.
在本研究中，我们在1,2 - 二甲基肼（DMH）处理的小鼠（一种结肠癌模型）中研究了膳食植物来源的葡萄糖神经酰胺（GlcCer）对结肠细胞因子含量的影响。DMH处理诱导了异常隐窝灶（ACF）的形成以及炎性细胞因子和趋化因子的产生。膳食GlcCer抑制了这些小鼠中ACF的形成和细胞因子的产生。特别是，膳食GlcCer抑制了趋化因子的产生。这些与GlcCer相关的抑制趋势与我们之前对硫酸葡聚糖钠盐（DSS）处理的小鼠的研究中观察到的趋势相似。这些结果为膳食GlcCer抑制DMH诱导的炎症提供了进一步的证据。
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