Hoffmann P
Prostaglandins Leukot Med. 1986 Feb;21(2):113-47. doi: 10.1016/0262-1746(86)90147-2.
A survey of the effects of dietary polyunsaturates on the function of the cardiovascular system is given. In isolated hearts of rats dietary linoleate supply increases both coronary flow and heart muscle function. Hearts of rats fed high amounts of linoleic acid are protected against catecholamine (over)-stimulation. Polyunsaturate rich vegetable oils are effective in lowering blood pressure in several murine hypertension models. This effect seems to be closely related to antihypertensive changes in kidney function and in the function of the arterial vessel wall. Dietary polyunsaturates augment the hypotensive effect of antihypertensive drugs. Cardiovascular effects of dietary polyunsaturates are at least partly mediated via changes in the prostanoid metabolism as well as a reduction of the sympathetic activity. Evidence has been accumulated that cardiovascular effects of dietary polyunsaturates in animal and man are comparable. The observed effects are discussed against the background of a reduced risk of cardiovascular disease after a polyunsaturate rich diet in man.
本文综述了膳食多不饱和脂肪酸对心血管系统功能的影响。在大鼠离体心脏中，膳食亚油酸供应可增加冠状动脉血流量和心肌功能。喂食大量亚油酸的大鼠心脏对儿茶酚胺（过度）刺激具有保护作用。富含多不饱和脂肪酸的植物油在几种小鼠高血压模型中可有效降低血压。这种作用似乎与肾功能和动脉血管壁功能的降压变化密切相关。膳食多不饱和脂肪酸可增强抗高血压药物的降压作用。膳食多不饱和脂肪酸的心血管效应至少部分是通过前列腺素代谢的变化以及交感神经活动的降低来介导的。已有证据表明，膳食多不饱和脂肪酸在动物和人类中的心血管效应具有可比性。在人类食用富含多不饱和脂肪酸的饮食后心血管疾病风险降低的背景下，对观察到的效应进行了讨论。
