Codde J P, Beilin L J, Croft K D
J Hypertens. 1984 Feb;2(1):65-71. doi: 10.1097/00004872-198402000-00012.
To study the influence of dietary modification of prostaglandin synthesis on blood pressure regulation, the effects of dietary enrichment with linoleic acid were compared with standard rat chow in three groups of 24 rats before and after renal artery constriction and contralateral nephrectomy. Dietary supplementation with 40 energy% sunflower seed oil or linseed oil respectively caused incorporation of linoleic or linolenic acids into tissue phospholipids. Relative to the sunflower seed oil, the linseed oil diet led to inhibition of prostanoid synthesis in kidney, serum or aorta in vitro and urine in vivo. Rats on both oil-rich diets had lower blood pressures than rats on a standard diet. Thus, partial suppression of prostaglandin synthesis did not accelerate one-kidney, one clip Goldblatt hypertension, nor did sunflower oil protect against hypertension in a way that could be specifically ascribed to changes in prostaglandin synthesis.
为研究前列腺素合成的饮食调整对血压调节的影响，在三组24只大鼠肾动脉缩窄及对侧肾切除前后，比较了富含亚油酸的饮食与标准大鼠饲料的效果。分别用含40%能量的向日葵籽油或亚麻籽油进行饮食补充，可使亚油酸或亚麻酸掺入组织磷脂中。相对于向日葵籽油，亚麻籽油饮食导致体外肾脏、血清或主动脉以及体内尿液中前列腺素合成受到抑制。两种富含油类饮食的大鼠血压均低于标准饮食的大鼠。因此，前列腺素合成的部分抑制并未加速单肾单夹型戈德布拉特高血压，向日葵油也未以可明确归因于前列腺素合成变化的方式预防高血压。
