Laboratory of Molecular and Structural Pathology, Gonçalo Moniz Institute, Fiocruz, Salvador, Brazil.
Department of Pathology, Faculty of Medicine, Federal University of Bahia, UFBA, Salvador, Brazil.
Front Immunol. 2022 Jan 28;13:833560. doi: 10.3389/fimmu.2022.833560. eCollection 2022.
Chagas disease is accompanied by a multisystem inflammatory disorder that follows infection. Alpha-tocopherol has been described as an antioxidant and a potential adjuvant to enhance immune responses to vaccines. Therefore, we have evaluated the immune response to infection upon alpha-tocopherol pre-administration. The results show that administration of alpha-tocopherol before the infection results in lower parasitemia and lower mortality of C57BL/6 mice infected with the strain. Alpha-tocopherol administration in normal C57BL/6 mice resulted in higher levels of IFN-γ production by T and NK cells before and after the infection with . More importantly, previous administration of alpha-tocopherol increased the production of IL-10 by T and myeloid suppressor cells and the formation of effector memory T cells while decreasing the expression of PD-1 on T cells. These results suggest that alpha-tocopherol may limit the appearance of dysfunctional T cells during the acute and early chronic phases of infection, contributing to control infection. In addition, alpha-tocopherol could diminish tissue inflammation and fibrosis in late acute disease. These results strongly suggest that alpha-tocopherol may be a helpful agent to be considered in Chagas disease.
恰加斯病伴随着感染后的多系统炎症性疾病。α-生育酚已被描述为一种抗氧化剂，可作为增强疫苗免疫反应的辅助剂。因此，我们评估了α-生育酚预先给药对 感染的免疫反应。结果表明，在感染前给予α-生育酚可导致感染 株的 C57BL/6 小鼠的寄生虫血症降低和死亡率降低。在正常的 C57BL/6 小鼠中给予α-生育酚，可导致在感染 前后 T 和 NK 细胞产生更高水平的 IFN-γ。更重要的是，α-生育酚的预先给药增加了 T 和髓样抑制细胞产生 IL-10 的能力，并形成效应记忆 T 细胞，同时降低 T 细胞上 PD-1 的表达。这些结果表明，α-生育酚可能限制了 感染急性和早期慢性阶段中功能失调的 T 细胞的出现，有助于控制感染。此外，α-生育酚可减少晚期急性疾病中的组织炎症和纤维化。这些结果强烈表明，α-生育酚可能是一种有助于治疗恰加斯病的药物。
