Kwak Seyul, Shin Seong A, Ko Hyunwoong, Kim Hairin, Oh Dae Jong, Youn Jung Hae, Lee Jun-Young, Kim Yu Kyeong
Department of Psychology, Pusan National University, Busan, Korea.
Department of Biomedical Sciences, Seoul National University, Seoul, Korea.
Dement Neurocogn Disord. 2022 Jan;21(1):17-29. doi: 10.12779/dnd.2022.21.1.17. Epub 2022 Jan 7.
Verbal and nonverbal fluency tests are the conventional methods for examining executive function in the elderly population. However, differences in impairments result in fluency tests in patients with mild cognitive impairments (MCIs) and Alzheimer's disease (AD) and in neural correlates underlying the tests still necessitate concrete evidence.
We compared the test performances in 27 normal controls, 28 patients with MCI, and 20 with AD, and investigated morphological changes in association with the test performances using structural magnetic imaging.
Patients with AD performed poorly across all the fluency tests, and a receiver operating characteristics curve analysis revealed that only category fluency test discriminated all the 3 groups. Association, category, and design fluency tests involved temporal and frontal regions, while letter fluency involved the cerebellum and caudate.
Category fluency is a reliable measure for screening patients with AD and MCI, and this efficacy might be related to morphological correlates that underlie semantic and executive processing.
言语和非言语流畅性测试是检查老年人群执行功能的传统方法。然而，轻度认知障碍（MCI）患者和阿尔茨海默病（AD）患者在流畅性测试中的损伤差异以及测试背后的神经相关性仍需要确凿证据。
我们比较了27名正常对照者、28名MCI患者和20名AD患者的测试表现，并使用结构磁共振成像研究了与测试表现相关的形态学变化。
AD患者在所有流畅性测试中表现不佳，受试者工作特征曲线分析显示，只有类别流畅性测试能够区分所有3组。联想、类别和设计流畅性测试涉及颞叶和额叶区域，而字母流畅性测试涉及小脑和尾状核。
类别流畅性是筛查AD和MCI患者的可靠指标，这种有效性可能与语义和执行加工背后的形态学相关性有关。
