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SLC30A1和SLC30A10在宫颈癌中的相关性及作用分析

The correlation and role analysis of SLC30A1 and SLC30A10 in cervical carcinoma.

作者信息

Zhang Jing, Chen Xin-Wei, Shu Li-Sha, Liu Chong-Dong

机构信息

Department of gynecology and obstetrics, Chao Yang Hospital of Capital Medical University, Beijing,100020, China.

Department of blood transfusion, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

出版信息

J Cancer. 2022 Jan 4;13(3):1031-1047. doi: 10.7150/jca.56777. eCollection 2022.

DOI:10.7150/jca.56777
PMID:35154468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8824890/
Abstract

: SLC30 family genes, also known as ZnT family genes, can keep cellular zinc levels within a physiological range by exporting zinc to extracellular space or by isolating zinc in the specific regions of cytoplasm when cellular zinc concentrations are elevated in human cells. There are growing evidences that dysregulated expression of SLC30 family genes can potentially influence tumorigenesis. However, the expression and prognostic value of SLC30 family genes in cervical carcinoma are poorly characterized. : In this study, we used many tools such as UALCAN, Kaplan-Meier Plotter, cBioPortal, LinkedOmics, FunRich, Metascape, GeneMANIA, Open targets and TISIDB to perform bioinformatics analysis of SLC30 family genes in cervical carcinoma. We found that the expression of SLC30A1/7/10 was significantly higher in cervical carcinoma than that in normal matched tissues, while SLC30A2/8 mRNA levels were decreased compared to normal tissues. For tumor stages, SLC30A1, SLC30A7 and SLC30A10 groups significantly varied. And a high expression of SLC30A1, SLC30A6, SLC30A8 and SLC30A10 was associated with worse overall survival in cervical carcinoma patients. Besides, we found that SLC30A1/10 may have a potential regulatory role in immune infiltration in cervical carcinoma. In addition, the results showed that the high expression of SLC30A1 was resistant to 79 drugs or small molecules; Two drugs (Neopeltolide and Tozasertib) can inhibit the high expression of SLC30A10 in cancers. : SLC30A1 and SLC30A10 can be recognized as potential diagnostic indicators and therapeutic targets in cervical carcinoma.

摘要

SLC30家族基因，也被称为锌转运体（ZnT）家族基因，当人体细胞内锌浓度升高时，可通过将锌输出到细胞外空间或在细胞质的特定区域隔离锌，从而将细胞内锌水平维持在生理范围内。越来越多的证据表明，SLC30家族基因的表达失调可能会影响肿瘤发生。然而，SLC30家族基因在宫颈癌中的表达及预后价值仍未得到充分研究。：在本研究中，我们使用了UALCAN、Kaplan-Meier Plotter、cBioPortal、LinkedOmics、FunRich、Metascape、GeneMANIA、Open targets和TISIDB等多种工具，对宫颈癌中SLC30家族基因进行生物信息学分析。我们发现，SLC30A1/7/10在宫颈癌中的表达显著高于正常匹配组织，而SLC30A2/8的mRNA水平与正常组织相比有所下降。在肿瘤分期方面，SLC30A1、SLC30A7和SLC30A10组有显著差异。SLC30A1、SLC30A6、SLC30A8和SLC30A10的高表达与宫颈癌患者较差的总生存期相关。此外，我们发现SLC30A1/10可能在宫颈癌的免疫浸润中具有潜在的调节作用。此外，结果表明SLC30A1的高表达对79种药物或小分子具有抗性；两种药物（新蛇床子素和托扎替布）可抑制癌症中SLC30A10的高表达。：SLC30A1和SLC30A10可被视为宫颈癌潜在的诊断指标和治疗靶点。

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本文引用的文献

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Zinc Modulates Several Transcription-Factor Regulated Pathways in Mouse Skeletal Muscle Cells.锌调节小鼠骨骼肌细胞中几种转录因子调节的途径。
Molecules. 2020 Nov 3;25(21):5098. doi: 10.3390/molecules25215098.
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Sci Rep. 2020 Oct 27;10(1):18352. doi: 10.1038/s41598-020-75012-w.
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Metalloimmunology: The metal ion-controlled immunity.金属免疫：金属离子调控的免疫。
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Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.Metascape 为系统水平数据集的分析提供了面向生物学家的资源。
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TISIDB: an integrated repository portal for tumor-immune system interactions.TISIDB：一个用于肿瘤-免疫系统相互作用的综合知识库门户。
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Cervical cancer.宫颈癌。
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