Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
Department of Biology, University of Pisa, S.S. 12 Abetone e Brennero 4, 56127 Pisa, Italy.
Oxid Med Cell Longev. 2022 Feb 4;2022:3313016. doi: 10.1155/2022/3313016. eCollection 2022.
Metal oxide nanoparticles (MO NPs) are increasingly employed in many fields with a wide range of applications from industries to drug delivery. Due to their semiconducting properties, metal oxide nanoparticles are commonly used in the manufacturing of several commercial products available in the market, including cosmetics, food additives, textile, paint, and antibacterial ointments. The use of metallic oxide nanoparticles for medical and cosmetic purposes leads to unavoidable human exposure, requiring a proper knowledge of their potentially harmful effects. This review offers a comprehensive overview of the possible toxicity of metallic oxide nanoparticles in zebrafish during both adulthood and growth stages, with an emphasis on the role of oxidative stress.
金属氧化物纳米粒子（MO NPs）在许多领域的应用越来越广泛，从工业到药物输送等领域都有涉及。由于其半导体特性，金属氧化物纳米粒子常用于制造市场上的几种商业产品，包括化妆品、食品添加剂、纺织品、油漆和抗菌软膏。金属氧化物纳米粒子在医疗和美容方面的应用导致不可避免的人体暴露，因此需要对其潜在的有害影响有适当的了解。本综述全面概述了成年期和生长阶段斑马鱼中金属氧化物纳米粒子的可能毒性，重点介绍了氧化应激的作用。
