Vanaroj Peeranate, Chaijaroenkul Wanna, Na-Bangchang Kesara
Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, 12120 Thailand.
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Pathumthani, 12120 Thailand.
Mol Clin Oncol. 2022 Mar;16(3):66. doi: 10.3892/mco.2022.2499. Epub 2022 Jan 19.
Cholangiocarcinoma (CCA) is an aggressive type of bile duct cancer that is characterized by a high mortality rate due to its late diagnosis and ineffective treatment. The aim of the present systematic review was to analyze the association between Notch signaling and CCA in terms of its pathogenesis, progression and potential treatment targets. Relevant information was gathered from the PubMed, ScienceDirect and Scopus databases using the search terms 'cholangiocarcinoma' AND 'Notch signaling'. Of the 90 articles identified, 28 fulfilled the eligibility criteria and were included in the analysis. It was concluded that overexpression/upregulation of Notch ligands, such as Jagged1 and Notch receptors (Notch1, Notch2 and Notch3), as well as upregulation of the upstream Notch signaling pathway, promoted CCA development and progression. In addition, downregulation of Notch1 signaling through several possible interventions appears to be a promising strategy for inhibition of CCA development and progression. Therefore, the Notch signaling pathway may be considered as a potential target for CCA control.
胆管癌（CCA）是一种侵袭性胆管癌，由于其诊断较晚且治疗效果不佳，死亡率很高。本系统综述的目的是从发病机制、进展和潜在治疗靶点方面分析Notch信号通路与CCA之间的关联。使用搜索词“胆管癌”和“Notch信号通路”从PubMed、ScienceDirect和Scopus数据库中收集相关信息。在鉴定出的90篇文章中，28篇符合纳入标准并被纳入分析。得出的结论是，Notch配体（如Jagged1）和Notch受体（Notch1、Notch2和Notch3）的过表达/上调，以及上游Notch信号通路的上调，促进了CCA的发生和进展。此外，通过几种可能的干预措施下调Notch1信号通路似乎是抑制CCA发生和进展的一种有前景的策略。因此，Notch信号通路可被视为控制CCA的潜在靶点。
