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The Neurophysiology of Caffeine as a Central Nervous System Stimulant and the Resultant Effects on Cognitive Function.咖啡因作为中枢神经系统兴奋剂的神经生理学及其对认知功能的影响
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Intralipid and haemodialysis in caffeine overdose.脂肪乳剂与血液透析在咖啡因过量中的应用。
BMJ Case Rep. 2020 May 14;13(5):e234256. doi: 10.1136/bcr-2020-234256.
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The clinical toxicology of caffeine: A review and case study.咖啡因的临床毒理学:综述与案例研究
Toxicol Rep. 2018 Nov 3;5:1140-1152. doi: 10.1016/j.toxrep.2018.11.002. eCollection 2018.
4
Caffeine and Arrhythmias: Time to Grind the Data.咖啡因与心律失常:是时候深入研究数据了。
JACC Clin Electrophysiol. 2018 Apr;4(4):425-432. doi: 10.1016/j.jacep.2018.01.012.
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Dangerous mistake: an accidental caffeine overdose.危险错误:意外的咖啡因过量。
BMJ Case Rep. 2018 Jun 8;2018:bcr-2018-224185. doi: 10.1136/bcr-2018-224185.
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The Safety of Ingested Caffeine: A Comprehensive Review.摄入咖啡因的安全性:全面综述
Front Psychiatry. 2017 May 26;8:80. doi: 10.3389/fpsyt.2017.00080. eCollection 2017.
7
β-Blockers, Cocaine, and the Unopposed α-Stimulation Phenomenon.β受体阻滞剂、可卡因与α受体激动无对抗现象
J Cardiovasc Pharmacol Ther. 2017 May;22(3):239-249. doi: 10.1177/1074248416681644. Epub 2016 Dec 14.
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Review of Caffeine-Related Fatalities along with Postmortem Blood Concentrations in 51 Poisoning Deaths.51例中毒死亡病例中与咖啡因相关的死亡及死后血液浓度回顾
J Anal Toxicol. 2017 Apr 1;41(3):167-172. doi: 10.1093/jat/bkx011.
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Electrocardiogram Abnormalities of Caffeine Overdose.咖啡因过量的心电图异常
Circ Arrhythm Electrophysiol. 2016 Jul;9(7). doi: 10.1161/CIRCEP.115.003088.
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Caffeine: cognitive and physical performance enhancer or psychoactive drug?咖啡因:认知和身体机能增强剂还是精神活性药物?
Curr Neuropharmacol. 2015 Jan;13(1):71-88. doi: 10.2174/1570159X13666141210215655.

咖啡因中毒:不受监管的非处方销售潜在致命补充剂。

Caffeine Intoxication: Unregulated, Over-the-Counter Sale of Potentially Deadly Supplements.

作者信息

Pina Cabral João, Sousa David L, Carvalho Catarina, Girao Adriana, Pacheco Mendes Adriano, Pina Rui

机构信息

Internal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.

Family Medicine, USF Novo Norte, ARS Norte, Arouca, PRT.

出版信息

Cureus. 2022 Jan 9;14(1):e21045. doi: 10.7759/cureus.21045. eCollection 2022 Jan.

DOI:10.7759/cureus.21045
PMID:35155012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8824417/
Abstract

Caffeine is an integral part of beverages, food, and medications. Severe intoxication of caffeine is rare, and reports are even scarcer. However, over-the-counter, unregulated sale of performance-enhancing compounds, such as caffeine, turns high-dose consumption into a real concern. Severe intoxication may be fatal, usually by malignant cardiac arrhythmia. We report a case of a 23-year-old university student who accidentally consumed about 100 times the amount present in an expresso of anhydrous caffeine.

摘要

咖啡因是饮料、食品和药物中不可或缺的一部分。严重的咖啡因中毒很罕见,相关报道更是稀少。然而,像咖啡因这样的提高成绩的化合物在非处方、不受监管的情况下销售,使得高剂量摄入成为一个切实令人担忧的问题。严重中毒可能是致命的,通常是由恶性心律失常导致。我们报告一例23岁大学生的病例,该学生意外摄入了约为一杯特浓咖啡中无水咖啡因含量100倍的量。