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食物过敏的预防:儿童早期与晚期引入食物过敏原

Food Allergy Prevention: Early Versus Late Introduction of Food Allergens in Children.

作者信息

Kakieu Djossi Sandrine, Khedr Anwar, Neupane Bandana, Proskuriakova Ekaterina, Jada Keji, Mostafa Jihan A

机构信息

Medical Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

出版信息

Cureus. 2022 Jan 9;14(1):e21046. doi: 10.7759/cureus.21046. eCollection 2022 Jan.

Abstract

The emergence of food allergies in children is crucial for various medical fields seeking a viable strategy for allergy prevention. The most well-recognized approach adopted by numerous health care and government institutions hinges on the delay in the introduction of food allergens, which supposedly protects infants from sensitization and decreases the possibility of allergy development. However, recent experimental findings indicate that the benefits of this approach might be overestimated, as early exposure to allergenic foods has been shown to yield more advantageous outcomes. Multiple investigations on the causes of allergic diseases report that avoiding food allergies might be related to early consumption of these allergens. Alternatively, delaying the contact with allergenic nourishments, explored in contemporary research, has been proven to result in a higher prevalence of allergies among children, originating such conditions as atopic diseases and extreme sensitization to foods. The current paper compares the two prominent strategies of allergenic food introduction, gathering the most pertinent modern evidence to distinguish whether exposure to food allergens should be delayed or advanced.

摘要

儿童食物过敏的出现对各个寻求可行过敏预防策略的医学领域至关重要。众多医疗保健和政府机构采用的最广为人知的方法取决于推迟引入食物过敏原,据认为这能保护婴儿不发生致敏并降低过敏发生的可能性。然而,最近的实验结果表明,这种方法的益处可能被高估了,因为早期接触致敏食物已被证明会产生更有利的结果。多项关于过敏性疾病病因的调查表明,避免食物过敏可能与早期食用这些过敏原有关。另外,当代研究中探讨的推迟接触致敏性食物已被证明会导致儿童过敏患病率更高,引发诸如特应性疾病和对食物极度敏感等情况。本文比较了引入致敏性食物的两种主要策略,收集了最相关的现代证据,以判别接触食物过敏原应推迟还是提前。

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