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60 cm源皮距下小多叶准直器(MLC)成形电子射野的实用剂量学考量

Practical Dosimetry Considerations for Small MLC-Shaped Electron Fields at 60 cm SSD.

作者信息

Eeden Déte Van, Sachse Karl N, Du Plessis Freek C P

机构信息

PhD, Department of Medical Physics, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

MSc, Department of Medical Physics, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

出版信息

J Biomed Phys Eng. 2022 Feb 1;12(1):101-108. doi: 10.31661/jbpe.v0i0.2004-1097. eCollection 2022 Feb.

Abstract

Superficial tumours can be treated with megavoltage electron beams. The underlying tissue can be spared through the steep dose fall-off gradients over a range of a few centimetres. An accurate Monte Carlo model for an Elekta Precise was determined and dose distribution was simulated. Dosimetric parameters were calculated to set guidelines for tumour irradiation. Elekta Precise multi-leaf collimators (MLC), which shaped electron fields were investigated using a benchmarked Monte Carlo model. BEAMnrc modelled the Elekta Precise and results were benchmarked against measurements. Percentage depth dose and beam profile data were simulated within 2% / 2 mm accuracy of the measured data. The DOSXYZnrc code simulated the 3-D dose data in water between 4 and 15 MeV. The relative (P) penumbra, percentage depth dose (PDD), range to 90% of dose maximum (R), dose fall-off range R (DFR), and the percentage bremsstrahlung dose (BSD), were extracted from the simulated data. The relative penumbra ranged from 90% to 10% at 6 MeV and 15 MeV, respectively. R values ranged between 0.8 cm at 4 MeV and 4.5 cm at 15 MeV. The DFR ranged between 0.8 cm at 4 MeV and 3.5 cm at 15 MeV. The BSD was the highest for low beam energies and small fields. Developed guidelines indicated that intermediate-sized MLC fields are most suited for therapy since they have lower BSD, longer R, shorter DFR but larger P. The DFR increases and R decreases for small fields at higher beam energies and more distal tissue will receive doses > 20%.

摘要

浅表肿瘤可用兆伏电子束治疗。通过几厘米范围内陡峭的剂量下降梯度,可使深层组织免受辐射。确定了用于医科达Precise直线加速器的精确蒙特卡罗模型,并模拟了剂量分布。计算剂量学参数以制定肿瘤照射指南。使用经过基准测试的蒙特卡罗模型研究了用于形成电子射野的医科达Precise多叶准直器(MLC)。BEAMnrc对医科达Precise直线加速器进行了建模,并将结果与测量值进行了基准对比。模拟的百分深度剂量和射野轮廓数据的精度在测量数据的2% / 2毫米范围内。DOSXYZnrc代码模拟了4至15 MeV水中的三维剂量数据。从模拟数据中提取了相对(P)半值层、百分深度剂量(PDD)、剂量最大值的90%处的射程(R)、剂量下降射程R(DFR)以及韧致辐射剂量百分比(BSD)。相对半值层在6 MeV和15 MeV时分别为90%至10%。R值在4 MeV时为0.8 cm至15 MeV时为4.5 cm之间。DFR在4 MeV时为0.8 cm至15 MeV时为3.5 cm之间。低束流能量和小射野时BSD最高。制定的指南表明,中等尺寸的MLC射野最适合治疗,因为它们的BSD较低、R较长、DFR较短但P较大。对于高束流能量下的小射野,DFR增加而R减小,更多的远端组织将接受>20%的剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6277/8819267/254928b7b853/JBPE-12-101-g001.jpg

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