Solignac A
Nouv Presse Med. 1978 Apr 1;7(13):1101-8.
Clinical applications involve heart failure during the acute phase of myocardial infarction, with the possibility of reducing the degree and extent of the perinecrotic ischaemic zone of the infarction. Treatment of this type would seem also to be particularly valuable in the provisional management of acute or sub-acute regurgitating valvular lesions: mitral insufficiency and interventricular communication secondary to an acute infarction, mitral and/or aortic regurgitation due the endocarditis. Finally, the results of oral vasodilators in the context of chronic refractory heart failure would seem ot be encouraging in the short term but their influence on long term prognosis is not known.
临床应用涉及心肌梗死急性期的心力衰竭，有可能减轻梗死灶周围缺血区的程度和范围。这种治疗方式在急性或亚急性反流性瓣膜病变的临时处理中似乎也特别有价值：急性梗死继发的二尖瓣关闭不全和室间隔缺损、心内膜炎导致的二尖瓣和/或主动脉反流。最后，口服血管扩张剂用于慢性难治性心力衰竭时，短期内效果似乎令人鼓舞，但它们对长期预后的影响尚不清楚。
