特应性皮炎与抑郁和自杀的关联：两样本孟德尔随机化研究。
Association of Atopic Dermatitis with Depression and Suicide: A Two-Sample Mendelian Randomization Study.
机构信息
Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
出版信息
Biomed Res Int. 2022 Feb 3;2022:4084121. doi: 10.1155/2022/4084121. eCollection 2022.
BACKGROUND
Atopic dermatitis (AD) has long been hypothesized to be associated with risk of depression and suicide, but the causal relationship between them is still unclear.
OBJECTIVE
To evaluate the causality between AD, depression, and suicide using a Mendelian randomization (MR) approach.
METHOD
We extracted summary-level data for AD, major depression, and suicidal ideation or attempt from published, nonoverlapping genome-wide association studies (GWAS). Inverse variance-weighted (IVW) analysis was used as the primary analysis. Alternate methods, including weighted median, MR Egger, MR pleiotropy residual sum and outlier, weighted mode, and leave-out analysis, were performed to assess pleiotropy.
RESULTS
13 SNPs (13,287 cases and 41,345 controls) were selected as instrumental variables (IVs). The IVW analysis indicated a statistically significant but small causal effect of AD on major depression (OR = 1.027, 95% CI 1.004-1.050; = 0.020). No significant evidence was observed for a causal effect of AD on suicide. No significant effect of pleiotropy was found.
CONCLUSION
AD has a significant but small effect on major depression, but not on suicide.
背景
特应性皮炎（AD）长期以来一直被认为与抑郁和自杀风险相关，但它们之间的因果关系仍不清楚。
目的
使用孟德尔随机化（MR）方法评估 AD、抑郁和自杀之间的因果关系。
方法
我们从已发表的非重叠全基因组关联研究（GWAS）中提取了 AD、重度抑郁症和自杀意念或尝试的汇总水平数据。反方差加权（IVW）分析被用作主要分析。还进行了替代方法，包括加权中位数、MR Egger、MR 多效性残差和异常值、加权模式和剔除分析，以评估多效性。
结果
选择了 13 个 SNP（13287 例病例和 41345 例对照）作为工具变量（IVs）。IVW 分析表明，AD 对重度抑郁症有统计学上显著但较小的因果作用（OR=1.027，95%CI 1.004-1.050；P=0.020）。AD 对自杀没有显著的因果作用。没有发现多效性的显著影响。
结论
AD 对重度抑郁症有显著但较小的影响，但对自杀没有影响。
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