Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, (UTHealth), Houston, Texas, USA.
Institute of Child Development, University of Minnesota, Minneapolis, Minnesota, USA.
Am J Med Genet B Neuropsychiatr Genet. 2022 Oct;189(7-8):221-246. doi: 10.1002/ajmg.b.32917. Epub 2022 Aug 17.
Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent need to advance research on its phenomenology and etiology. Epidemiological studies have demonstrated that suicidal behavior is heritable, suggesting that genetic and epigenetic information may serve as biomarkers for suicide risk. Here we systematically review the literature on genetic and epigenetic alterations observed in phenotypes across the full range of self-injurious thoughts and behaviors (SITB). We included 577 studies focused on genome-wide and epigenome-wide associations, candidate genes (SNP and methylation), noncoding RNAs, and histones. Convergence of specific genes is limited across units of analysis, although pathway-based analyses do indicate nervous system development and function and immunity/inflammation as potential underlying mechanisms of SITB. We provide suggestions for future work on the genetic and epigenetic correlates of SITB with a specific focus on measurement issues.
自杀是一种多方面且尚未被充分理解的临床结局，因此迫切需要深入研究其现象学和病因学。流行病学研究表明，自杀行为具有遗传性，这表明遗传和表观遗传信息可能是自杀风险的生物标志物。在这里，我们系统地回顾了有关在各种自伤思想和行为（SITB）表型中观察到的遗传和表观遗传改变的文献。我们纳入了 577 项专注于全基因组和全表观基因组关联、候选基因（SNP 和甲基化）、非编码 RNA 和组蛋白的研究。尽管基于途径的分析确实表明神经系统发育和功能以及免疫/炎症是 SITB 的潜在潜在机制，但特定基因在分析单位之间的一致性是有限的。我们提供了有关 SITB 的遗传和表观遗传相关性的未来工作建议，特别关注测量问题。
