Bos R P, Koopman J P, Theuws J L, Kennis H M, Henderson P T
Toxicology. 1986 Apr;39(1):85-92. doi: 10.1016/0300-483x(86)90161-7.
Rats treated orally with direct brown 95, a benzidine-based dye, widely used in dyeing of textiles, plastics, paper and other materials, showed 2 peaks of excretion of mutagenic products in urine, one between 6 h and 18 h after administration and one about 30 h later. Prevention of coprophagy by fitting neck collars resulted in the disappearance of the second peak. Oral administration of carminic acid resulted in a biphasic excretion of this dye in the feces, due to coprophagy. The excretion pattern of mutagens in urine after administration of direct brown 95 corresponds with the excretion pattern in the feces of orally administered carminic acid.
用直接棕95（一种基于联苯胺的染料，广泛用于纺织品、塑料、纸张和其他材料的染色）经口处理的大鼠，其尿液中诱变产物的排泄出现两个峰值，一个在给药后6小时至18小时之间，另一个在约30小时后。通过佩戴颈圈防止食粪导致第二个峰值消失。由于食粪，口服胭脂红酸导致该染料在粪便中呈双相排泄。给予直接棕95后尿液中诱变剂的排泄模式与口服胭脂红酸后粪便中的排泄模式一致。
