Rızvanoğlu Ibrahim Halil, Kısacık Bünyamin
Department of Orthopedics and Traumatology, NCR International Hospital, Şehitkamil, Gaziantep, Turkey.
Department of Rheumatology, Gaziantep Medicalpark Hospital, Şehitkamil, Gaziantep, Turkey.
Eur J Rheumatol. 2022 Apr;9(2):111-113. doi: 10.5152/eujrheum.2022.21124.
Achilles enthesopathy is a pain caused due to inflammation of the insertion area of the Achilles tendon on the posterosuperior aspect of the calcaneus. Sometimes, isolated Achilles enthesopathy can be occurred, while, mostly, it is observed with rheumatological diseases. We herein aimed to report a case presentation, sitagliptin-induced enthesopathy, and literature review on musculoskeletal manifestations of gliptins. A 63-year-old man was diagnosed with type II diabetes mellitus, recently started sitagliptin. After the sitagliptin administration, bilateral Achilles enthesopathy has emerged. Afterward, he was diagnosed with sitagliptin-induced enthesopathy, and it was stopped. Following the termination of sitagliptin, all signs and symptoms related to Achilles enthesopathy disappeared. Gliptin-induced enthesopathy was reported rarely. To the best of our knowledge, this is the second case of gliptin-induced Achilles enthesopathy in the literature. Gliptins might not innocent drugs about musculoskeletal disorders.
跟腱附着点病是由跟腱在跟骨后上方附着区域的炎症引起的疼痛。有时，会出现孤立的跟腱附着点病，而在大多数情况下，它与风湿性疾病相关。我们在此旨在报告一例病例、西他列汀诱发的附着点病，并对格列汀类药物的肌肉骨骼表现进行文献综述。一名63岁男性被诊断为2型糖尿病，最近开始服用西他列汀。服用西他列汀后，双侧出现跟腱附着点病。之后，他被诊断为西他列汀诱发的附着点病，并停用了该药物。停用西他列汀后，所有与跟腱附着点病相关的体征和症状均消失。格列汀类药物诱发的附着点病报道很少。据我们所知，这是文献中第二例格列汀类药物诱发的跟腱附着点病。格列汀类药物对于肌肉骨骼疾病可能并非无害药物。
