Steinmuller D R
Transplant Proc. 1986 Apr;18(2 Suppl 1):158-67.
CsA levels are definitely useful for monitoring patients one to six months post-renal transplantation. They help to document that individuals are complying with their medication therapy and taking the medication. They may identify patients who are not absorbing the drug due to associated gastrointestinal problems. There is a correlation, although weak, with both rejection and nephrotoxicity. A variety of other factors may limit the usefulness of this correlation, but serial measurements of the CsA trough level will help when making clinical decisions for these patients. Finally, monitoring of CsA levels will help to identify drug interactions and to determine quantitatively the impact of these interactions. Thus, a more appropriate dosage modification of CsA can be determined because of the availability of specific drug levels. Pharmacokinetic modeling may be useful to assess variability in absorption and metabolism of the drug in individual patients. The practical usefulness of this technique, however, remains less clear due to its expense and inconvenience.
环孢素A（CsA）水平对于肾移植术后一至六个月的患者监测肯定是有用的。它们有助于证明个体正在遵守药物治疗方案并按时服药。它们可能识别出由于相关胃肠道问题而未吸收药物的患者。虽然与排斥反应和肾毒性的相关性较弱，但存在这种关联。多种其他因素可能会限制这种相关性的实用性，但连续测量CsA谷值水平在为这些患者做出临床决策时会有所帮助。最后，监测CsA水平将有助于识别药物相互作用，并定量确定这些相互作用的影响。因此，由于有特定的药物水平可供参考，可以确定更合适的CsA剂量调整。药代动力学建模可能有助于评估个体患者中药物吸收和代谢的变异性。然而，由于其费用和不便，这项技术的实际实用性仍不太明确。
