Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, XizangMinzu University, Xianyang, Shaanxi, 712082, China.
Department of Rehabilitation Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China.
Future Oncol. 2022 May;18(15):1861-1872. doi: 10.2217/fon-2021-0973. Epub 2022 Feb 14.
This study was designed to evaluate the contribution of variants to gastric cancer (GC) risk in a Chinese Han population. The genotypes of polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs. rs140081212 (OR = 0.51, p = 4.50 × 10), rs1057941 (OR = 0.48, p = 1.19 × 10) and rs2990220 (OR = 0.46, p = 7.34 × 10) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. This research suggested that polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.
本研究旨在评估变异在中国汉族人群胃癌（GC）风险中的作用。多态性的基因型使用 Agena MassARRAY 平台进行检测。采用 logistic 回归分析计算比值比（OR）和 95%置信区间（CI）。rs140081212（OR=0.51，p=4.50×10）、rs1057941（OR=0.48，p=1.19×10）和 rs2990220（OR=0.46，p=7.34×10）降低 GC 风险，尤其是胃腺癌的风险。有趣的是，变异对 GC 易感性的贡献与年龄、性别、BMI、吸烟和饮酒有关。本研究表明，多态性可能为中国汉族人群 GC 的发生提供一种保护作用。
