Department of Physiology, Aziz Fatima Medical College, Faisalabad, Pakistan.
Department of Physiology, The University of Faisalabad, Pakistan.
J Pak Med Assoc. 2021 Jan;71(1(B)):195-200. doi: 10.47391/JPMA.818.
To compare surfactant protein-D levels in type 2 diabetics and non-diabetics, and to explore its link with random blood glucose and extra-pulmonary infections.
The case-control study was conducted in 2012-13 at the Dow University of Health Sciences, Karachi, and comprised diabetic cases and non-diabetic controls. Extra pulmonary infections, body mass index and random blood glucose levels were noted and serum surfactant protein-D was analysed using enzynme-linked immunosorbent assay. Data was analysed using SPSS 20.
Of the 120 subjects, 60(50%) each were cases and controls. Significant negative correlation was found between surfactant protein-D and infections (rs= -0.495, p=0.0001). A negative association between random blood glucose and surfactant protein-D was found, but it was not significant (p=0.15). Relative risk for extra-pulmonary infections in diabetics was 2 times higher than the controls (odds ratio: 2.10, p=0.04).
Serum surfactant protein-D was found to have negative association with extra-pulmonary infections.
比较 2 型糖尿病患者和非糖尿病患者中表面活性蛋白-D 的水平，并探讨其与随机血糖和肺外感染的关系。
这是一项 2012-2013 年在卡拉奇的道大学健康科学中心进行的病例对照研究，纳入了糖尿病患者和非糖尿病对照者。记录肺外感染、体重指数和随机血糖水平，并采用酶联免疫吸附试验分析血清表面活性蛋白-D。使用 SPSS 20 进行数据分析。
在 120 名受试者中，病例和对照组各有 60 名（各占 50%）。研究发现，表面活性蛋白-D 与感染呈显著负相关（rs=-0.495，p=0.0001）。虽然发现随机血糖与表面活性蛋白-D 之间存在负相关，但无统计学意义（p=0.15）。糖尿病患者发生肺外感染的相对风险是对照组的 2 倍（比值比：2.10，p=0.04）。
血清表面活性蛋白-D 与肺外感染呈负相关。
