Jawed Shireen, Saeed Marium, Parveen Naila
Department: Physiology, Islam Medical & Dental College, Sialkot, Karachi.
Final Year MBBS Student, Liaquat University of Medical and Health Sciences, Jamshoro, Karachi.
J Pak Med Assoc. 2015 Nov;65(11):1210-3.
To find out the rate of respiratory tract infections in diabetic and non-diabetic individuals and their relation with surfactant protein D.
The cross-sectional study was conducted at Dow University of Health Sciences, Karachi, from September 2011 to April 2012, and comprised subjects of both genders between ages of 30 and 60 years. The subjects were divided into four groups: diabetic obese, non-diabetic obese, diabetic non-obese, and non-diabetic-non-obese. A structured questionnaire was used to collect information about respiratory tract infections. Serum surfactant protein D levels were analysed using human surfactant protein D enzyme-linked immunosorbent assay kit. Statistical analysis was performed using SPSS 16.
Of the 90 subjects, there were 20(22.2%) diabetic obese, 30(33.3%) non-diabetic obese, 10(11.1%) diabetic non-obese, and 30(33.3%) non-diabetic-non-obese. The overall mean age was 36.6±103 years. Among the diabetic obese, 15(75%) had respiratory tract infections which was higher than the other study groups, and patients having respiratory tract infections had lower surfactant protein D levels than those who did not have infections (p=0.01).
Diabetic obese subjects had greater rate of recurrent respiratory tract infections and had lower concentration of serum surfactant protein D compared to subjects without respiratory tract infections.
了解糖尿病患者和非糖尿病患者呼吸道感染的发生率及其与表面活性蛋白D的关系。
2011年9月至2012年4月在卡拉奇的道健康科学大学进行了一项横断面研究，研究对象为年龄在30至60岁之间的男女。研究对象被分为四组：糖尿病肥胖组、非糖尿病肥胖组、糖尿病非肥胖组和非糖尿病非肥胖组。使用结构化问卷收集呼吸道感染的信息。使用人表面活性蛋白D酶联免疫吸附测定试剂盒分析血清表面活性蛋白D水平。使用SPSS 16进行统计分析。
90名研究对象中，糖尿病肥胖组20人（22.2%），非糖尿病肥胖组30人（33.3%），糖尿病非肥胖组10人（11.1%），非糖尿病非肥胖组30人（33.3%）。总体平均年龄为36.6±103岁。糖尿病肥胖组中，15人（75%）有呼吸道感染，高于其他研究组，且有呼吸道感染的患者其表面活性蛋白D水平低于无感染的患者（p=0.01）。
与无呼吸道感染的患者相比，糖尿病肥胖患者反复呼吸道感染的发生率更高，血清表面活性蛋白D浓度更低。
