Department of Nephrology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China.
Department of Clinical Pharmacy and Pharmacology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China.
J Pak Med Assoc. 2021 Jan;71(1(B)):367-369. doi: 10.47391/JPMA.1244.
Calciphylaxis, a rare disease mainly seen in patients with chronic kidney disease, is characterised by ischaemic skin damages and excruciating pain. Calciphylaxis has poor prognosis which often results in amputation and high mortality. Although guidelines for the management of calciphylaxis are not available, sodium thiosulfate has shown efficacy in many clinical reports. We report the case of a 64-year-old advanced calciphylaxis male patient who had two amputations due to intolerable pain manifested as deteriorating ulcer. After he was treated with intravenous sodium thiosulfate (STS), his pain was significantly relieved with a healing trend of the big wound. One more amputation for the remission of intractable pain was avoided. The treatment experience indicates that sodium thiosulfate is of great value in quick pain relief and reducing suffering of calciphylaxis patients.
钙化防御，一种罕见的疾病，主要见于慢性肾脏病患者，其特征为缺血性皮肤损伤和剧痛。钙化防御预后不良，常导致截肢和高死亡率。虽然钙化防御的管理指南尚不可用，但硫代硫酸钠在许多临床报告中显示出疗效。我们报告了一例 64 岁的晚期钙化防御男性患者，由于疼痛难以忍受（表现为恶化的溃疡）而进行了两次截肢。在接受静脉注射硫代硫酸钠（STS）治疗后，他的疼痛明显缓解，大伤口有愈合趋势。避免了一次因难治性疼痛而进行的截肢。治疗经验表明，硫代硫酸钠在快速缓解疼痛和减轻钙化防御患者痛苦方面具有重要价值。
