Gläser V, Hallebach V, Hans S
Z Urol Nephrol. 1986 Jan;79(1):19-27.
One patient with Bartter-syndrome and two patients with pseudo-Bartter-syndrome in abuse of laxatives and diuretics, respectively, were examined clinically and biochemically. The causes of the severe disturbances of the electrolyte metabolism are demonstrated. The differential diagnosis between Bartter- and pseudo-Bartter-syndrome is discussed, exact investigations of electrolyte balance of intake and output are decisive. In consequent therapy with prostaglandin inhibitors (indomethacin), aldosterone antagonists (verospirone) and oral electrolyte supply the prognosis of the Bartter-syndrome is favourable. Little successful is the treatment of the pseudo-Bartter-syndrome. On account of the severe psychic disturbance of the personality a renunciation of laxatives and diuretics, respectively, is frequently not to be achieved.
分别对1例患有巴特综合征的患者以及2例分别因滥用泻药和利尿剂而患有假性巴特综合征的患者进行了临床和生化检查。阐述了电解质代谢严重紊乱的原因。讨论了巴特综合征和假性巴特综合征的鉴别诊断,对摄入和排出的电解质平衡进行精确检查具有决定性意义。在使用前列腺素抑制剂(吲哚美辛)、醛固酮拮抗剂(螺内酯)进行后续治疗并口服补充电解质时,巴特综合征的预后良好。假性巴特综合征的治疗效果不佳。由于患者存在严重的精神人格障碍,往往无法分别戒除泻药和利尿剂。