Fang Dan-Na, Zheng Chang-Wu, Ma Ye-Ling
Medical College, Shaoxing University, Shaoxing 312000, Zhejiang Province, China.
Medical College, Shaoxing University, Shaoxing 312000, Zhejiang Province, China.
J Integr Med. 2023 Jan;21(1):17-25. doi: 10.1016/j.joim.2022.09.005. Epub 2022 Sep 28.
The root of Scutellaria baicalensis Georgi, also called Huangqin, is frequently used in traditional Chinese medicine. In ancient China, S. baicalensis root was used to clear heat, protect the fetus, and avoid a miscarriage for thousands of years. In modern times, pregnancy-related diseases can seriously affect maternal and fetal health, but few systematic studies have explored the mechanisms and potential targets of S. baicalensis root in the treatment of pregnancy-related diseases. Flavonoids (baicalein, wogonin and oroxylin A) and flavonoid glycosides (baicalin and wogonoside) are the main chemical components in the root of S. baicalensis. This study presents the current understanding of the major chemical components in the root of S. baicalensis, focusing on their traditional uses, potential therapeutic effects and ethnopharmacological relevance to pregnancy-related disorders. The mechanisms, potential targets and experimental models of S. baicalensis root for ameliorating pregnancy-related diseases, such as recurrent spontaneous abortion, preeclampsia, preterm birth, fetal growth restriction and gestational diabetes mellitus, are highlighted.
黄芩的根，又称黄芩，常用于传统中药。在中国古代，黄芩根被用于清热、安胎、避免流产达数千年之久。在现代，与妊娠相关的疾病会严重影响母婴健康，但很少有系统研究探讨黄芩根治疗妊娠相关疾病的机制和潜在靶点。黄酮类化合物（黄芩素、汉黄芩素和木犀草素A）和黄酮苷（黄芩苷和汉黄芩苷）是黄芩根中的主要化学成分。本研究介绍了目前对黄芩根主要化学成分的认识，重点关注其传统用途、潜在治疗作用以及与妊娠相关疾病的民族药理学相关性。文中突出了黄芩根改善复发性自然流产、子痫前期、早产、胎儿生长受限和妊娠期糖尿病等妊娠相关疾病的机制、潜在靶点及实验模型。
