Surface imprinted core-shell nanorod for selective extraction of glycoprotein.

In this paper, combining phenylboronic affinity, surface imprinting, and magnetic FeO, a novel surface imprinted core-shell nanorod (FeO@SiO/MIPs) was developed for glycoprotein extraction. The FeO@SiO/MIPs was prepared in water solution using dopamine as functional monomer. The FeO@SiO/MIPs showed high binding capacity (175.2 mg/g) and fast mass transfer rate (40 min) toward the template protein (ovalbumin, OVA). In addition, the successful extraction of OVA from egg white confirmed the outstanding selectivity of the obtained material. All these results demonstrated that the FeO@SiO/MIPs had broad application prospects in glycoprotein recognition, biomedical research and clinical diagnosis.