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小儿阻塞性睡眠呼吸暂停综合征的治疗:同时扩大多发性上颌骨和下颌骨,效果如何?一项回顾性非随机对照队列研究。

Management of the pediatric OSAS: what about simultaneously expand the maxilla and advance the mandible? A retrospective non-randomized controlled cohort study.

机构信息

Aix-Marseille Univ, Univ Gustave Eiffel, LBA, Marseille, France; YooMed, Montpellier, France.

INSERM, INRAE, Univ Rennes 1, CHU de Rennes, Nutrition Metabolisms and Cancer, Rennes, France; Department of Dentistry, Pontchaillou University Hospital, Rennes, France.

出版信息

Sleep Med. 2022 Feb;90:135-141. doi: 10.1016/j.sleep.2022.01.007. Epub 2022 Jan 13.

DOI:10.1016/j.sleep.2022.01.007
PMID:35158293
Abstract

OBJECTIVE/BACKGROUND: This retrospective non-randomized controlled cohort study aimed to evaluate the efficiency of simultaneous maxillary expansion and mandibular advancement for the management of pediatric OSAS.

PATIENTS/METHODS: The sample was composed of 94 children treated with an innovative orthopedic device to correct a Class II malocclusion associated with an OSAS. Polysomnographic recordings were performed before and after the treatment. We also included a group of 113 age-matched control patients who had the same pathologies, but who did not receive the orthopedic treatment at the time they undergone polysomnographic exams. Statistical tests evaluated the significance of the evolution of these data, both in treated and untreated control patients.

RESULTS

After nine months (±3 months) of treatment, respiratory OSAS symptoms significantly improved: the AHI significantly decreased as it became inferior to the pathological threshold (<1) for 53% of the treated patients' sample, with a greater proportion within the youngest age group (63%). Only two patients still presented a moderate OSAS after treatment, with an AHI slightly superior to 5. This positive evolution of OSAS respiratory symptoms was not observed within the control group, highlighting the real impact of the orthopedic treatment over the children's natural growth. However, sleep remained fragmented following the treatment.

CONCLUSIONS

This study confirmed that simultaneous maxillary expansion and mandibular advancement induced a modification of the maxilla-mandibular anatomy, helping in the significant improvement of the respiratory OSAS symptoms. Then, considering these preliminary results, pediatric OSAS can be managed with this new orthopedic strategy, especially if it is performed early.

摘要

目的/背景:本回顾性非随机对照队列研究旨在评估上颌扩张和下颌前伸同时进行治疗儿童阻塞性睡眠呼吸暂停低通气综合征(OSAS)的效果。

患者/方法:该样本由 94 名接受创新性矫形装置治疗以矫正伴有 OSAS 的 II 类错颌的儿童组成。在治疗前后进行多导睡眠图记录。我们还纳入了一组 113 名年龄匹配的对照患者,他们有相同的病理,但在接受多导睡眠图检查时未接受矫形治疗。统计检验评估了治疗和未治疗对照患者这些数据演变的显著性。

结果

治疗 9 个月(±3 个月)后,呼吸 OSAS 症状显著改善:呼吸暂停低通气指数(AHI)显著降低,53%的治疗患者样本的 AHI 低于病理阈值(<1),且最小年龄组的比例更高(63%)。仅 2 名患者在治疗后仍存在中度 OSAS,AHI 略高于 5。在对照组中未观察到 OSAS 呼吸症状的这种积极演变,突出了矫形治疗对儿童自然生长的实际影响。然而,治疗后睡眠仍不完整。

结论

本研究证实上颌扩张和下颌前伸同时进行可引起上颌-下颌解剖结构的改变,有助于显著改善呼吸 OSAS 症状。因此,考虑到这些初步结果,儿童 OSAS 可以采用这种新的矫形策略进行治疗,尤其是在早期进行治疗时。

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