Dental Clinic, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, Hebei, 061000, China.
Clin Oral Investig. 2024 Jul 24;28(8):442. doi: 10.1007/s00784-024-05837-6.
Class II malocclusion, particularly class II division 1, poses a significant orthodontic challenge with implications for both aesthetics and health. This study aimed to explore the impact of twin-block (TB) combined with maxillary expansion treatment (TB-ME) on upper airway dimensions and inflammatory profiles in adolescents with skeletal Class II Division 1 malocclusion in adolescent.
Ninety-two eligible patients were randomly assigned to two groups: TB-ME treatment and traditional McLaughlin Bennett Trevisi (MBT) straight-wire orthodontic treatment (Control). Cephalometric lateral X-ray scans were conducted before and after treatment to assess skeletal changes, including SNA, ANB, and SNB angles, which are essential to assess the anteroposterior relationships of the maxilla and mandible to the cranial base. We also measured the upper airway volumes and areas. Concentrations of inflammatory factors including intercellular adhesion molecule 1 (ICAM-1), matrix metallopeptidase 2 (MMP2), and interleukin 8 (IL-8) of gingival crevicular fluid analysis (GCF) were detected by enzyme-linked immunosorbent assay.
TB-ME treatment induced significant improvement in cephalometric parameters, including a decrease in SNA and ANB angles and an increase in SNB angle. Upper airway volumes and areas increased significantly in both groups, with TB-ME showing greater improvements. GCF analysis revealed a reduction in ICAM-1, MMP2, and IL-8 concentrations in the TB-ME group compared to the Control group.
TB-ME treatment demonstrates multifaceted improvements in skeletal malocclusion, upper airway dimensions, and inflammatory profiles in adolescents with class II division 1 malocclusion, showing the promise of TB-ME in addressing the complexities associated with class II malocclusion.
II 类错颌畸形，尤其是 II 类 1 分类，对美观和健康都有很大的影响，这是正畸的一个挑战。本研究旨在探讨双板（TB）联合上颌扩弓治疗（TB-ME）对骨性 II 类 1 分类错颌青少年的上气道尺寸和炎症谱的影响。
92 名符合条件的患者被随机分为两组：TB-ME 治疗组和传统的 Mc Laughlin Bennett Trevisi（MBT）直丝弓正畸治疗组（对照组）。治疗前后进行头颅侧位 X 线片检查，评估骨骼变化，包括 SNA、ANB 和 SNB 角，这些角度对于评估上颌和下颌相对于颅底的前后关系至关重要。我们还测量了上气道的体积和面积。通过酶联免疫吸附试验检测龈沟液（GCF）中炎症因子的浓度，包括细胞间黏附分子 1（ICAM-1）、基质金属蛋白酶 2（MMP2）和白细胞介素 8（IL-8）。
TB-ME 治疗组在头影测量参数方面有显著改善，包括 SNA 和 ANB 角的减小和 SNB 角的增加。两组的上气道体积和面积均显著增加，TB-ME 组的改善更为显著。GCF 分析显示，与对照组相比，TB-ME 组的 ICAM-1、MMP2 和 IL-8 浓度降低。
TB-ME 治疗组在骨性 II 类 1 分类错颌青少年的骨骼错颌、上气道尺寸和炎症谱方面表现出多方面的改善，表明 TB-ME 在解决 II 类错颌相关复杂性方面具有潜力。
