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使用长期培养的供体材料进行角膜移植。

Corneal transplantation using long-term cultured donor material.

作者信息

Andersen J, Ehlers N

出版信息

Acta Ophthalmol (Copenh). 1986 Feb;64(1):93-6. doi: 10.1111/j.1755-3768.1986.tb06879.x.

DOI:10.1111/j.1755-3768.1986.tb06879.x
PMID:3515836
Abstract

Twenty-seven corneal transplantations with a mean duration of donor incubation of 14.3 days (group 1) and 36 transplantations with a mean duration of incubation of 29.8 days (group 2) were followed for 18 months. No significant difference was found in graft survival between the two groups (81 versus 80%). Almost all graft failures were found among pre-operatively defined high-risk cases, i.e. previously transplanted and/or vascularized recipient cornea. The profile of the corneal thickness curve was almost identical in the two groups, and normal values were reached in both. Visual acuity was 0.5 or better in 23% of the cases in group 1, and 35% in group 2. These figures were highly influenced by co-existing and complicating eye disease i.e. amblyopia, cataract, macular degeneration and glaucoma. The results show that 2 weeks and 4 weeks cultured cornea do not differ with respect to graft survival and thickness. The over all results indicate that long-term cultured donor material is suitable for corneal transplantation and fully comparable to material stored by other methods.

摘要

对27例供体角膜平均保存14.3天的角膜移植术(第1组)和36例供体角膜平均保存29.8天的角膜移植术(第2组)进行了为期18个月的随访。两组间植片存活率无显著差异(分别为81%和80%)。几乎所有的植片失败都发生在术前定义的高危病例中,即先前接受过移植和/或角膜血管化的受体。两组角膜厚度曲线几乎相同,且均达到正常值。第1组23%的病例视力为0.5或更好,第2组为35%。这些数据受并存和并发眼病(即弱视、白内障、黄斑变性和青光眼)的影响很大。结果表明,保存2周和4周的角膜在植片存活和厚度方面无差异。总体结果表明,长期保存的供体材料适用于角膜移植,且与其他保存方法的材料完全可比。

相似文献

1
Corneal transplantation using long-term cultured donor material.使用长期培养的供体材料进行角膜移植。
Acta Ophthalmol (Copenh). 1986 Feb;64(1):93-6. doi: 10.1111/j.1755-3768.1986.tb06879.x.
2
The influence of donor age and post mortem time on corneal graft survival and thickness when employing banked donor material (A five-year follow-up).
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[Preservation of human corneas in organ culture: results of a feasibility clinical protocol].[人体角膜在器官培养中的保存:一项可行性临床方案的结果]
Bull Soc Ophtalmol Fr. 1990 Apr;90(4):429-32.
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The suitability of corneas stored by organ culture for penetrating keratoplasty and influence of donor and recipient factors on 5-year graft survival.器官培养保存角膜用于穿透性角膜移植的适宜性及供体和受体因素对 5 年移植物存活率的影响。
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[Human grafts preserved at +37 degrees C. Initial clinical results].
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Corneal transplantation using 4-week banked donor material. Long-term results.使用储存4周的供体材料进行角膜移植。长期结果。
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Biocompatibility evaluation of bioprinted decellularized collagen sheet implanted in vivo cornea using swept-source optical coherence tomography.应用扫频源光学相干断层扫描评估生物打印去细胞胶原片在体内角膜中的生物相容性。
J Biophotonics. 2019 Nov;12(11):e201900098. doi: 10.1002/jbio.201900098. Epub 2019 Jul 23.
2
Penetrating keratoplasty in south east London 1981-1986: epidemiological aspects and demands on medical resources.1981 - 1986年伦敦东南部的穿透性角膜移植术:流行病学特征及对医疗资源的需求
J R Soc Med. 1990 Apr;83(4):245-8. doi: 10.1177/014107689008300414.
3
Effect of donor cornea preservation in tissue culture and in McCarey-Kaufmann medium on corneal graft rejection and visual acuity.
组织培养及麦卡雷-考夫曼培养基中供体角膜保存对角膜移植排斥反应和视力的影响。
Doc Ophthalmol. 1991;78(3-4):273-8. doi: 10.1007/BF00165691.