Rønningen H, Solheim L F, Barth E, Langeland N
Acta Orthop Scand. 1986 Feb;57(1):15-8. doi: 10.3109/17453678608993207.
We evaluated the bone-forming potential of isogeneic bone marrow combined with antigen-extracted, autolyzed allogeneic bone matrix (AAA bone a.m. Urist). The purpose of the experiment was to evaluate bone-inducing materials for application in orthopaedic devices designed for fixation by bone ingrowth into a porous surface. The bone-forming materials were packed into tubes of porous fiber titanium and placed in the back musculature of rats for 12 or 25 days. At 12 days the combination of bone marrow and AAA bone had produced more bone than marrow only. At 25 days, however, there was no difference. The bone-inducing materials produced substantial amounts of new bone, and may become an adjuvant for achieving fixation by bone ingrowth. In particular, a combination of AAA bone and marrow might enhance fixation at a very early postoperative stage.
我们评估了同基因骨髓与抗原提取、自溶的同种异体骨基质（乌里斯AAA骨）相结合的成骨潜力。本实验的目的是评估骨诱导材料在设计用于通过骨长入多孔表面进行固定的骨科器械中的应用。将成骨材料装入多孔纤维钛管中，并置于大鼠背部肌肉组织中12天或25天。在12天时，骨髓与AAA骨的组合比仅使用骨髓产生了更多的骨。然而，在25天时，两者没有差异。骨诱导材料产生了大量新骨，可能成为通过骨长入实现固定的辅助材料。特别是，AAA骨与骨髓的组合可能在术后早期增强固定效果。
