Rønningen H, Solheim L F, Langeland N
Acta Orthop Scand. 1985 Feb;56(1):67-71. doi: 10.3109/17453678508992983.
Bone-inducing materials have been investigated for the purpose of augmenting bone formation in implants made of porous fiber titanium. The bone-inducing materials used were: (1) Bone from the iliac crest of inbred rats (isografts), (2) Antigen-extracted, autolyzed, demineralized bone from outbred rats (AAA bone a.m. Urist), and (3) AAA bone combined with bone marrow from inbred rats. Tubes of fiber titanium were packed with bone-inducing materials and implanted in the back musculature of inbred rats. Bone formation was assessed by labelling with 3H-proline (collagen synthesis) and 47Ca (mineral deposit) and by content of calcium of the harvested implants. Isografts and AAA bone with marrow yielded a substantial amount of new bone. Without the marrow, AAA bone yielded very small amounts of new bone.
为了促进由多孔纤维钛制成的植入物中的骨形成，人们对骨诱导材料进行了研究。所使用的骨诱导材料有：(1) 近交系大鼠髂嵴骨（同基因移植物），(2) 从远交系大鼠中提取抗原、自溶、脱矿的骨（AAA骨，由Urist提出），以及(3) AAA骨与近交系大鼠骨髓的组合。将装有骨诱导材料的纤维钛管植入近交系大鼠的背部肌肉组织中。通过用3H-脯氨酸（胶原蛋白合成）和47Ca（矿物质沉积）标记以及所收获植入物的钙含量来评估骨形成。同基因移植物和含骨髓的AAA骨产生了大量新骨。不含骨髓时，AAA骨产生的新骨量非常少。
