Zardab Mohamed, Stasinos Konstantinos, Grose Richard P, Kocher Hemant M
Barts Cancer Institute, Queen Mary University, London EC1M 6BQ, UK.
Cancers (Basel). 2022 Jan 21;14(3):528. doi: 10.3390/cancers14030528.
AHNAK2 is a protein discovered in 2004, with a strong association with oncogenesis in various epithelial cancers. It has a large 616 kDa tripartite structure and is thought to take part in the formation of large multi-protein complexes. High expression is found in clear cell renal carcinoma, pancreatic ductal adenocarcinoma, uveal melanoma, and lung adenocarcinoma, with a relation to poor prognosis. Little work has been done in exploring the function and relation AHNAK2 has with cancer, with early studies showing promising potential as a future biomarker and therapeutic target.
AHNAK2是一种于2004年发现的蛋白质，与多种上皮癌的肿瘤发生密切相关。它具有一个616 kDa的大型三方结构，被认为参与大型多蛋白复合物的形成。在透明细胞肾细胞癌、胰腺导管腺癌、葡萄膜黑色素瘤和肺腺癌中发现其高表达，且与预后不良有关。在探索AHNAK2的功能及其与癌症的关系方面所做的工作较少，早期研究显示其作为未来生物标志物和治疗靶点具有广阔的潜力。
