Kim Young Tae
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul 03080, Korea.
Cancer Research Institute, Genomic Medicine Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 03080, Korea.
Cancers (Basel). 2022 Jan 29;14(3):715. doi: 10.3390/cancers14030715.
With the increased popularity of low-dose computed tomography (LDCT), many patients present with pulmonary ground-glass nodules (GGNs), and the appropriate diagnostic and management strategy of those lesions make physicians be on the horn of the clinical dilemma. As there is not enough data available to set universally acceptable guidelines, the management of GGNs may be different. If GGN is an incidental finding through LDCT, the lesion should be followed according to the current guidelines. We recommend a multidisciplinary team discussion to be initiated if a new solid component develops or the solid portion size grows on follow-up CT as the risk of malignancy is high. Attempts to preoperatively biopsy solid components in part-solid GGNs are often not feasible and not helpful in clinical settings. Currently, if malignancy is suspected, a surgical biopsy with the guidance of various localization methods is recommended. If malignancy is confirmed, sub-lobar resection may provide an excellent oncologic outcome.
随着低剂量计算机断层扫描（LDCT）的日益普及，许多患者出现了肺部磨玻璃结节（GGN），而这些病变的恰当诊断和管理策略使医生陷入了临床困境。由于没有足够的数据来制定普遍可接受的指南，GGN的管理可能会有所不同。如果GGN是通过LDCT偶然发现的，应根据当前指南对病变进行随访。如果在随访CT上新出现实性成分或实性部分大小增大，由于恶性风险较高，我们建议启动多学科团队讨论。在部分实性GGN中术前对实性成分进行活检的尝试在临床环境中往往不可行且无帮助。目前，如果怀疑为恶性，建议在各种定位方法的引导下进行手术活检。如果确诊为恶性，亚肺叶切除可能会带来良好的肿瘤学结果。
