Freihat Omar, Zoltán Tóth, Pinter Tamas, Kedves András, Sipos Dávid, Repa Imre, Kovács Árpád, Zsolt Cselik
Department of Medical Imaging, Faculty of Health Sciences, University of Pécs, 7621 Pécs, Hungary.
Doctoral School of Health Sciences, University of Pécs, 7621 Pécs, Hungary.
Cancers (Basel). 2022 Feb 8;14(3):847. doi: 10.3390/cancers14030847.
This study aimed to assess the association of 18F-Fluorodeoxyglucose positron-emission-tomography (18F-FDG/PET) and DWI imaging parameters from a primary tumor and their correlations with clinicopathological factors.
We retrospectively analyzed primary tumors in 71 patients with proven HNC. Primary tumor radiological parameters: DWI and FDG, as well as pathological characteristics were analyzed. Spearman correlation coefficient was used to assess the correlation between DWI and FDG parameters, ANOVA or Kruskal-Wallis, independent sample t-test, Mann-Whitney test, and multiple regression were performed on the clinicopathological features that may affect the 18F- FDG and apparent-diffusion coefficient (ADC) of the tumor.
No significant correlations were observed between DWI and any of the 18F-FDG parameters ( > 0.05). SUVmax correlated with N-stages ( = 0.023), TLG and MTV correlated with T-stages ( = 0.006 and = 0.001), and ADC correlated with tumor grades ( = 0.05). SUVmax was able to differentiate between N+ and N- groups ( = 0.004).
Our results revealed a non-significant correlation between the FDG-PET and ADC-MR parameters. FDG-PET-based glucose metabolic and DWI-MR-derived cellularity data may represent different biological aspects of HNC.
本研究旨在评估18F-氟脱氧葡萄糖正电子发射断层扫描（18F-FDG/PET）与原发肿瘤的弥散加权成像（DWI）影像参数之间的关联及其与临床病理因素的相关性。
我们回顾性分析了71例经证实患有头颈部癌（HNC）患者的原发肿瘤。分析原发肿瘤的放射学参数：DWI和FDG，以及病理特征。采用Spearman相关系数评估DWI与FDG参数之间的相关性，对可能影响肿瘤18F-FDG及表观扩散系数（ADC）的临床病理特征进行方差分析（ANOVA）或Kruskal-Wallis检验、独立样本t检验、Mann-Whitney检验及多元回归分析。
未观察到DWI与任何18F-FDG参数之间存在显著相关性（P>0.05）。最大标准摄取值（SUVmax）与N分期相关（P = 0.023），总病变糖酵解（TLG）和代谢组织体积（MTV）与T分期相关（P = 0.006和P = 0.001），ADC与肿瘤分级相关（P = 0.05）。SUVmax能够区分N+和N-组（P = 0.004）。
我们的结果显示FDG-PET与ADC-MR参数之间无显著相关性。基于FDG-PET的葡萄糖代谢和基于DWI-MR的细胞密度数据可能代表了HNC不同的生物学特性。
