最大标准化摄取值（SUV Max）对早期舌鳞状细胞癌隐匿性淋巴结转移及预后预测的意义
Significance of SUV Max for Predicting Occult Lymph Node Metastasis and Prognosis in Early-Stage Tongue Squamous Cell Carcinoma.
作者信息
Xu Chunmiao, Li Hailiang, Seng Dongjie, Liu Fei
机构信息
Department of Radiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Department of Otorhinolaryngology, Children's Hospital to Zhengzhou University, Zhengzhou University, Zhengzhou, China.
出版信息
J Oncol. 2020 Mar 30;2020:6241637. doi: 10.1155/2020/6241637. eCollection 2020.
OBJECTIVE
Our goal was to clarify the significance of SUV max for predicting occult lymph node metastasis and prognosis in early-stage tongue squamous cell carcinoma (SCC).
METHODS
cT1-2N0 tongue SCC patients who underwent a preoperative PET-CT examination were prospectively enrolled. The association between SUV max and occult lymph node metastasis was analyzed. The main study endpoint was locoregional control (LRC). The Cox model was used to determine the independent factors.
RESULTS
A total of 120 patients were included for analysis, and the median SUV max was 9.7. In 60 patients with an SUV max ≤9.7, 5 patients had occult metastasis; in 60 patients with an SUV max >9.7, 13 patients had occult metastasis, and the difference was significant (=0.041). In patients with an SUV max ≤9.7, the 5-year LRC rate was 93%; in patients with an SUV max >9.7, the 5-year LRC rate was 81%, and the difference was significant (=0.045).
CONCLUSION
An SUV max >9.7 was a marker for occult lymph node metastasis and could decrease LRC in patients with cT1-2N0 tongue SCC.
目的
我们的目标是阐明最大标准摄取值（SUV max）在预测早期舌鳞状细胞癌（SCC）隐匿性淋巴结转移及预后方面的意义。
方法
前瞻性纳入术前行PET-CT检查的cT1-2N0舌SCC患者。分析SUV max与隐匿性淋巴结转移之间的关联。主要研究终点为局部区域控制（LRC）。采用Cox模型确定独立因素。
结果
共纳入120例患者进行分析，SUV max中位数为9.7。在60例SUV max≤9.7的患者中，5例有隐匿性转移；在60例SUV max>9.7的患者中，13例有隐匿性转移，差异有统计学意义（=0.041）。在SUV max≤9.7的患者中，5年LRC率为93%；在SUV max>9.7的患者中，5年LRC率为81%，差异有统计学意义（=0.045）。
结论
SUV max>9.7是隐匿性淋巴结转移的一个标志物，并且会降低cT1-2N0舌SCC患者的LRC。
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